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Tiran, A; Pieber, T; Tiran, B; Halwachs-Baumann, G; Wilders-Truschnig, M.
Photometric determination of HbA1c levels in clinical practice
Dtsch Med Wochenschr. 1994; 119(23):833-836 Doi: 10.1055/s-2008-1058768
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Leading authors Med Uni Graz: Tiran Andreas
Co-authors Med Uni Graz: Baumann Gabriele; Pieber Thomas; Tiran Beate; Truschnig-Wilders Martini
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Abstract:: This study was undertaken to evaluate the routine use of a new immunological photometer to measure the concentration of HbA1c in whole blood from 155 patients. The basis of the measurement is a latex agglutination reaction in which a monoclonal antibody as epitope recognizes glucose bound to HbA1c. The result is available within 9 min. High-pressure liquid chromatography (HPLC) served as control method. The photometer proved to be very precise (all coefficients of variant < 2.5%), and the values obtained agreed well with those by HPLC (y = 0.952x-0.12; r = 0.986; P < 0.001). The reference ranges for the photometrically measured HbA1c values (4.4-5.9%), obtained for 40 patients, agreed well with those by HPLC (4.6-6.2%). Interference study discovered no effect on the measured value by anaemia, polycythaemia or high rheuma factor (n = 31). In 12 patients on dialysis the photometer recorded significantly lower values than HPLC (P < 0.0005). It is possible that in these cases the photometer values are more accurate because the method is not affected by carbamylated haemoglobin. False results were obtained by the photometer in two patients with leucocytosis (79,000 and 216,000/microliters, respectively) due to chronic lymphocytic leukaemia.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Anemia - blood; Chromatography, High Pressure Liquid -; Female -; Hemoglobin A, Glycosylated - analysis; Humans -; Latex Fixation Tests -; Male -; Middle Aged -; Photometry - methods; Polycythemia - blood; Reference Values -; Regression Analysis -; Renal Dialysis -; Rheumatoid Factor - analysis; Sensitivity and Specificity -