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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Furthner, D; Weghuber, D; Dalus, C; Lukas, A; Stundner-Ladenhauf, HN; Mangge, H; Pixner, T.
Nonalcoholic Fatty Liver Disease in Children with Obesity: Narrative Review and Research Gaps.
Horm Res Paediatr. 2022; 95(2):167-176
Doi: 10.1159/000518595
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Mangge Harald
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- Abstract:
- BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the leading hepatic disease in children, ranging from steatosis to steatohepatitis and fibrosis. Age, sex, hormonal levels, pubertal stages, genetic risk- and epigenetic factors are among the many influencing factors. Appearing predominantly in children with obesity, but not exclusively, it is the liver's manifestation of the metabolic syndrome but can also exist as an isolated entity. SUMMARY: Pediatric NAFLD differs from the adult phenotype. This narrative review on NAFLD in children with obesity provides an overview of the current knowledge on risk factors, screening, and diagnostic methods, as well state-of-the-art treatment. The recent discussion on the proposition of a new nomenclature - Metabolic [Dysfunction-] Associated Liver Disease - is featured, and current gaps of knowledge are discussed. KEY MESSAGES: Currently, there is no international consensus on screening and monitoring of pediatric NAFLD. With lifestyle interventions being the cornerstone of treatment, no registered pharmacological treatment for pediatric NAFLD is available. Development and validation of additional noninvasive biomarkers, scores and imaging tools suitable to subcategorize, screen and monitor pediatric patients are necessary. With a variety of upcoming and promising agents, clear recommendations for pediatric nonalcoholic steatohepatitis trials are urgently needed.
- Find related publications in this database (using NLM MeSH Indexing)
- Child - administration & dosage
- Humans - administration & dosage
- Life Style - administration & dosage
- Liver - administration & dosage
- Metabolic Syndrome - administration & dosage
- Non-alcoholic Fatty Liver Disease - complications, diagnosis, therapy
- Obesity - administration & dosage
- Find related publications in this database (Keywords)
- Nonalcoholic fatty liver disease
- MAFLD
- Obesity
- Pediatric