Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Licht, P; Fluhr, H; Neuwinger, J; Wallwiener, D; Wildt, L.
Is human chorionic gonadotropin directly involved in the regulation of human implantation?
MOL CELL ENDOCRINOL. 2007; 269(1-2): 85-92. Doi: 10.1016/j.mce.2006.09.016
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Fluhr Herbert
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: The regulation of human implantation is not fully understood. hCG as one of the earliest embryonal signals may be a major regulator in the parakrine embryo-endometrial communication. The expression of full-length hCG/LH-receptor mRNA could be demonstrated in human endometrium throughout the follicular and secretory phase of the menstrual cycle. In contrast, in early pregnancy decidua only truncated variants could be detected. To investigate direct effects of hCG on the human endometrium, an intrauterine microdialysis device was developed to measure parakrine mediators within the uterine cavity in vivo. Using this system, hCG was applied in the secretory phase and the endometrial response was evaluated. The administration of hCG (500 IU/ml) provoked a significant inhibition of intrauterine IGFBP-1 and M-CSF, while LIF, VEGF and MMP-9 were significantly stimulated. Taken together there appear to be multiple direct effects of hCG on the endometrium that precede the classical endocrine role of the hormone. (c) 2007 Published by Elsevier Ireland Ltd.
Find related publications in this database (Keywords): LH-receptor; mRNA; IGFBP-1; hCG; implantation