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SHR Neuro Cancer Cardio Lipid Metab Microb
Immanuel, J; Simmons, D; Desoye, G; Corcoy, R; Adelantado, JM; Devlieger, R; Lapolla, A; Dalfra, MG; Bertolotto, A; Harreiter, J; Wender-Ozegowska, E; Zawiejska, A; Dunne, FP; Damm, P; Mathiesen, ER; Jensen, DM; Andersen, LLT; Hill, DJ; Jelsma, JGM; Snoek, FJ; Scharnagl, H; Galjaard, S; Kautzky-Willer, A; VAN Poppel, MNM.
Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women.
DIABETES RES CLIN PR. 2020; 168(5): 108378-108378.
Doi: 10.1016/j.diabres.2020.108378
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Desoye Gernot
- Scharnagl Hubert
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- Abstract:
- To investigate the performance of early pregnancy HbA1c for predicting gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in obese women. Post hoc analysis using data from the Vitamin D And Lifestyle Intervention for GDM prevention trials conducted across 9 European countries (2012-2014). Pregnant women (BMI ≥ 29 kg/m2) underwent a baseline HbA1c and oral glucose tolerance tests at < 20 weeks, 24-28 weeks, and 35-37 weeks. Women with GDM were referred for treatment. Among the 869 women tested, the prevalence of GDM was 25.9% before 20 weeks, with a further 8.6% at 24-28 weeks. The areas under the curves for HbA1c at the two time points were 0.55 (0.50-0.59) and 0.54 (0.47-0.61), respectively. An early HbA1c ≥ 5.7% (39 mmol/mol) (N = 111) showed low sensitivity (18.2%) with 89.1% specificity for GDM before 20 weeks, at 24-28 weeks (sensitivity of 8.0% and specificity of 88.6% after excluding early GDM), and throughout gestation (sensitivity of 15.9% and specificity of 89.4%). The ≥ 5.7% (39 mmol/mol) threshold was significantly associated with concurrent GDM before 20 weeks (adjusted OR (aOR) 2.77(1.39-5.51)) and throughout gestation (aOR 1.72 (1.02-2.89)), but not adverse pregnancy outcomes. Early pregnancy HbA1c is of limited use for predicting either GDM or adverse outcomes in overweight/obese European women. Copyright © 2020. Published by Elsevier B.V.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Diabetes, Gestational - epidemiology
- Diabetes, Gestational -
- Female -
- Glycated Hemoglobin A - analysis
- Humans -
- Obesity - complications
- Obesity - epidemiology
- Pregnancy -
- Pregnancy Outcome - epidemiology
- Prevalence -
- Find related publications in this database (Keywords)
- Diagnostic threshold
- Gestational diabetes mellitus
- Hemoglobin A(1c)
- Odds Ratio
- Pregnancy
- Pregnancy outcome