Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Faustmann, G; Tiran, B; Trajanoski, S; Obermayer-Pietsch, B; Gruber, HJ; Ribalta, J; Roob, JM; Winklhofer-Roob, BM.
Activation of nuclear factor-kappa B subunits c-Rel, p65 and p50 by plasma lipids and fatty acids across the menstrual cycle.
Free Radic Biol Med. 2020; 160:488-500
Doi: 10.1016/j.freeradbiomed.2020.08.012
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- Leading authors Med Uni Graz
- Faustmann Gernot
- Co-authors Med Uni Graz
- Gruber Hans-Jürgen
- Obermayer-Pietsch Barbara
- Roob Johannes
- Tiran Beate
- Trajanoski Slave
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- Abstract:
- This study focused on a comprehensive analysis of the canonical activation pathway of the redox-sensitive transcription factor nuclear factor-kappa B (NF-κB) in peripheral blood mononuclear cells, addressing c-Rel, p65 and p50 activation in 28 women at early (T1) and late follicular (T2) and mid (T3) and late luteal (T4) phase of the menstrual cycle, and possible relations with fasting plasma lipids and fatty acids. For the first time, strong inverse relations of c-Rel with apolipoprotein B were observed across the cycle, while those with LDL cholesterol, triglycerides as well as saturated (SFA), particularly C14-C22 SFA, monounsaturated (MUFA), and polyunsaturated fatty acids (PUFA) clustered at T2. In contrast, p65 was positively related to LDL cholesterol and total n-6 PUFA, while p50 did not show any relations. C-Rel was not directly associated with estradiol and progesterone, but data suggested an indirect C22:5n-3-mediated effect of progesterone. Strong positive relations between estradiol and individual SFA, MUFA and n-3 PUFA at T1 were confined to C18 fatty acids; C18:3n-3 was differentially associated with estradiol (positively) and progesterone (inversely). Given specific roles of c-Rel activation in immune tolerance, inhibition of c-Rel activation by higher plasma apolipoprotein B and individual fatty acid concentrations could have clinical implications for female fertility.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Nucleus - administration & dosage
- Fatty Acids - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Leukocytes, Mononuclear - administration & dosage
- Menstrual Cycle - administration & dosage
- NF-kappa B - administration & dosage
- Transcription Factor RelA - administration & dosage
- Find related publications in this database (Keywords)
- Nuclear factor-kappa B
- NF-kappa B
- c-Rel
- p65
- RelA
- p50
- Fatty acids
- n-3 Fatty acids
- n-6 Fatty acids
- Lipids
- Cholesterol
- LDL-cholesterol
- Apolipoprotein B
- Apolipoprotein A-I
- Menstrual cycle
- Peripheral blood mononuclear cells
- PBMC
- Canonical pathway
- Alpha-linolenic acid
- Docosapentaenoic acid