Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smola, MG; Ratschek, M; Hauser, H; Amann, W; Veith, G; Ruppitsch, U; Steindorfer, P.
Nonpalpable Breast-Cancer - Histological Results After Preoperative Marketing of 397 Nonpalpable Breast-Lesions
ONKOLOGIE. 1991; 14: 518-523.
Doi: 10.1159/000217037
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Smola Michael
- Co-Autor*innen der Med Uni Graz
- Hauser Hubert
- Ratschek Manfred
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- Abstract:
- The consecutive resection of mammographically detected non-palpable breast lesions after preoperative marking leads to an increase in the percentage of early diagnosis of small breast cancer, a non-screened population induced. Between 1/1/1983 and 12/31/1990, biopsies were performed in 397 female patients with non-palpable suspicious malignant breast lesions detected by mammography. Preoperative tissue-targeting was done by the radiologists using staining dye. 313 (79%) biopsies out of 397 biopsies showed benign lesions, the diagnosis breast cancer was found in 84 patients (21%), with 64 invasive and 20 in-situ carcinomas, corresponding with a 21% cancer biopsy rate. The average size of the carcinomas was 9.3 mm. 19 (22.6%) of the tumors were less than 5 mm size, 58 (69%) less than 10 mm, 80 out of 84 less than 20 mm (95%). 32 (38%) were in accordance with the definition of minimal breast cancer. The diagnosis breast cancer correlated with the radiological pattern of density in 24 (21.4%) of the biopsies, with the pattern of a non-palpable tumor in 25 (17.7%) cases and with microcalcifications in 31 (24.4%) biopsies, We found axillary lymphnode metastases in eleven patients (18%), three of them died after a mean follow-up period of 4729 months. No axillary metastases were found in 15 patients with in-situ carcinoma. The average number of dissected axillary lymph nodes was 13. In 45 (53.5%) cases of breast cancer we performed breast conserving treatment, in 38 cases (46.5%) modified radical mastectomy, and in one case simple mastectomy. Preoprative targeting, on contrast to blind biopsy, leads to the precise localisation of the lesion, a small incision and enables a slight tissue-excision without cosmetic deformation by primary marginal resection. The intraoperatively histologically determined resection margins allow for a minimal re-excision rate. The detection of non-palpable breast cancer leads to the improvement of curative treatment and over-all survival rates because of higher proportion of lymph node negative cases.
- Find related publications in this database (Keywords)
- Breast
- Nonpalpable Lesions
- Preoperative Targeting
- Non-Invasive/Invasive Cancer
- Surgical Treatment