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SHR Neuro Cancer Cardio Lipid Metab Microb

Zalaudek, I; Conforti, C; Guarneri, F; Vezzoni, R; Deinlein, T; Hofmann-Wellenhof, R; Longo, C; Moscarella, E; Kittler, H; Argenziano, G; Giuffrida, R.
Clinical and dermoscopic characteristics of congenital and noncongenital nevus-associated melanomas.
J Am Acad Dermatol. 2020; 83(4):1080-1087 Doi: 10.1016/j.jaad.2020.04.120
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Leading authors Med Uni Graz: Zalaudek Iris
Co-authors Med Uni Graz: Hofmann-Wellenhof Rainer; Kränke Teresa Maria
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Abstract:: No specific features of nevus-associated melanoma (NAM) are currently defined. To identify clinical/dermoscopic features of NAM. Retrospective evaluation of histopathologically diagnosed NAM. Eighty of 165 NAMs had a clinically recognizable nevus component, often raised or nodular, most frequently characterized by different morphologic clones and/or colors. In 111 of 165 NAMs, dermoscopy showed a nevus component, prevalently characterized by regular dots/clods and structureless brown areas. Clinically, the melanoma component was eccentric/peripheral in 45 of 80 cases and central in 35 of 80; dermoscopically, the figures were 59 of 111 and 52 of 111, respectively. Melanomas associated with congenital nevi (C-NAMs) occur at a younger age and have a thicker Breslow depth than melanomas associated with acquired nevi (NC-NAMs). Dermoscopically, regular dots/globules characterize C-NAMs, and hypopigmented structureless areas characterize NC-NAMs. Retrospective analysis. C-NAMs are more often central to a congenital nevus, with a clod/globular or structureless brown pattern, typical of young patients. NC-NAMs are frequently hypopigmented nodules/plaques, eccentric/peripheral, with hypopigmented structureless areas, typical of older patients. Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (Keywords): dermoscopy; melanoma; nevogenesis; nevus; nevus-associated melanoma; skin cancer