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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Depaoli, MR; Hay, JC; Graier, WF; Malli, R.
The enigmatic ATP supply of the endoplasmic reticulum.
Biol Rev Camb Philos Soc. 2019; 94(2):610-628
Doi: 10.1111/brv.12469
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- Leading authors Med Uni Graz
- Depaoli Maria Rosa
- Malli Roland
- Co-authors Med Uni Graz
- Graier Wolfgang
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- Abstract:
- The endoplasmic reticulum (ER) is a functionally and morphologically complex cellular organelle largely responsible for a variety of crucial functions, including protein folding, maturation and degradation. Furthermore, the ER plays an essential role in lipid biosynthesis, dynamic Ca2+ storage, and detoxification. Malfunctions in ER-related processes are responsible for the genesis and progression of many diseases, such as heart failure, cancer, neurodegeneration and metabolic disorders. To fulfill many of its vital functions, the ER relies on a sufficient energy supply in the form of adenosine-5'-triphosphate (ATP), the main cellular energy source. Despite landmark discoveries and clarification of the functional principles of ER-resident proteins and key ER-related processes, the mechanism underlying ER ATP transport remains somewhat enigmatic. Here we summarize ER-related ATP-consuming processes and outline our knowledge about the nature and function of the ER energy supply. © 2018 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.
- Find related publications in this database (Keywords)
- endoplasmic reticulum (ER)
- ATP
- ATP transporter
- secretory pathway
- protein quality control
- ER stress
- unfolded protein response (UPR)
- ERAD