Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Biebl, A; Hartmann, G; Bernhard, C; Bechter, E; Luckner-Hornischer, A; Frühwirth, M; Heuberger, S; Offner, F; Barbieri, V; Simma, B.
Vaccine strategies of meningococcal disease: results of a 10-year population-based study.
Eur J Pediatr. 2005; 164(12):735-740
Doi: 10.1007/s00431-005-1719-7
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- Leading authors Med Uni Graz
- Biebl Ariane
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- Abstract:
- Invasive meningococcal disease (IMD) is an important cause of morbidity and mortality in children and adults. This study was conducted to determine a possible increase in IMD in recent years with special interest focused on serogroup C disease. From January 1st 1993 to December 31st 2002, IMD was studied in one million residents of Austria. We used active, population-based surveillance data from the Office of Public Health. A total of 126 patients with positive blood and/or cerebrospinal fluid culture or positive swabs for Neisseria meningitidis were studied. The median age of all patients was 9.5 years (range 1 month to 63 years). The average incidence of all IMD subgroups was 1.05 cases per 100,000 person years and was highest in children 0-4 years old (7.08 cases per 100,000 person years) followed by young adults aged 15 to 19 years (4.35 cases per 100,000 person years). Serogroup C IMD occurred in 1.30 cases/100,000 person years in patients aged 0 to 4 years and in 1.92 cases/100,000 person years in patients aged 15 to 19 years. Overall mortality was 11.1%. There was a significant increase (P =0.001) in IMD due to serogroup B disease within the last 10 years. In contrast, serogroup C disease did not increase during the last decade. Currently, we do not recommend mass vaccination against serogroup C disease in Austria, but young adults aged 15 to 19 years display a high incidence of meningococcal C disease. In this age group, vaccination against serogroup C disease should be considered.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Adult - epidemiology
- Child -
- Child, Preschool -
- Humans -
- Infant -
- Mass Vaccination -
- Meningococcal Infections - epidemiology
- Meningococcal Infections - prevention & control
- Meningococcal Vaccines - administration & dosage
- Middle Aged -
- Neisseria meningitidis, Serogroup C -
- Seasons -
- Find related publications in this database (Keywords)
- epidemiology
- meningococcal disease
- surveillance
- vaccination