Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Knot, HJ; Laher, I; Sobie, EA; Guatimosim, S; Gomez-Viquez, L; Hartmann, H; Song, LS; Lederer, WJ; Graier, WF; Malli, R; Frieden, M; Petersen, OH.
Twenty years of calcium imaging: cell physiology to dye for.
MOL INTERV. 2005; 5(2): 112-127.
Doi: 10.1124/mi.5.2.8
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- Co-authors Med Uni Graz
- Graier Wolfgang
- Malli Roland
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- Abstract:
- The use of fluorescent dyes over the past two decades has led to a revolution in our understanding of calcium signaling. Given the ubiquitous role of Ca(2+) in signal transduction at the most fundamental levels of molecular, cellular, and organismal biology, it has been challenging to understand how the specificity and versatility of Ca(2+) signaling is accomplished. In excitable cells, the coordination of changing Ca(2+) concentrations at global (cellular) and well-defined subcellular spaces through the course of membrane depolarization can now be conceptualized in the context of disease processes such as cardiac arrhythmogenesis. The spatial and temporal dimensions of Ca(2+) signaling are similarly important in non-excitable cells, such as endothelial and epithelial cells, to regulate multiple signaling pathways that participate in organ homeostasis as well as cellular organization and essential secretory processes.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Calcium Signaling - metabolism
- Cell Physiology - metabolism
- Endoplasmic Reticulum - metabolism
- Endothelial Cells - cytology
- Epithelial Cells - metabolism
- Fluorescent Dyes - pharmacology
- Humans - pharmacology
- Models, Biological - pharmacology
- Muscle, Smooth, Vascular - cytology
- Rats - cytology
- Sarcoplasmic Reticulum - metabolism
- Signal Transduction - metabolism
- Time Factors - metabolism