Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Werten, S; Kohler, C; Bayer, NJ; Steinmetz, I; Hinrichs, W.
Structural analysis and knock-out of a Burkholderia pseudomallei homolog of the eukaryotic transcription coactivator PC4.
Gene. 2016; 577(2): 140-147.
Doi: 10.1016/j.gene.2015.11.037
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Steinmetz Ivo
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- Abstract:
- Homologs of the eukaryotic transcription coactivator PC4, which also functions in DNA repair and oxidative stress, were recently identified in prokaryotes. Crystallographic analysis of BPSL1147, a putative homolog from the pathogen Burkholderia pseudomallei K96243, reveals a highly conserved core structure and suggests a nucleic acid binding mode similar to that of PC4. Knock-out and complementation experiments do not reveal distinguishing phenotypes under normal growth conditions or in the presence of H2O2, arguing against a critical role in repair or the oxidative stress response of Burkholderia. These results may reflect redundancy or point at a bacteriophage origin of Burkholderia PC4 homologs.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Sequence -
- Bacterial Proteins - chemistry
- Bacterial Proteins - genetics
- Binding Sites -
- Burkholderia pseudomallei - genetics
- Burkholderia pseudomallei - metabolism
- Molecular Sequence Data -
- Mutation -
- Oxidative Stress -
- Protein Binding -
- Transcription Factors - chemistry
- Transcription Factors - genetics
- Find related publications in this database (Keywords)
- Positive cofactor 4
- Transcription
- DNA replication, recombination and repair
- Oxidative stress
- Bacteriophage