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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Enko, D; Meinitzer, A; Scharnagl, H; Stojakovic, T; Kleber, ME; Delgado, GE; Zelzer, S; Drechsler, C; Krämer, BK; Wanner, C; März, W; Woitas, RP.
Prospective cohort studies of beta-trace protein and mortality in haemodialysis patients and patients undergoing coronary angiography.
Nephrol Dial Transplant. 2018; 33(11):1984-1991
Doi: 10.1093/ndt/gfy025
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- Leading authors Med Uni Graz
- Enko Dietmar
- Co-authors Med Uni Graz
- März Winfried
- Meinitzer Andreas
- Scharnagl Hubert
- Stojakovic Tatjana
- Zelzer Sieglinde
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- Abstract:
- Beta-trace protein (BTP) is a low-molecular-weight glycoprotein, which may serve as an endogenous biomarker of kidney function and cardiovascular risk. We examined cardiovascular and all-cause mortality according to BTP concentrations in 2962 individuals referred for coronary angiography from the Ludwigshafen Risk and Cardiovascular Health study and in 907 patients with Type 2 diabetes mellitus undergoing haemodialysis from the German Diabetes and Dialysis (4D) study. Haemodialysis patients had considerably higher median (interquartile range) BTP concentrations [6.00 (4.49-7.96) mg/L] and experienced a 4-fold increased mortality rate compared with coronary angiography patients [BTP concentration: 0.55 (0.44-0.67) mg/L]. After adjustment for age, sex, cardiovascular risk factors and creatinine, 4D patients in the highest quartile (>7.96 mg/L) had a 1.6-fold increased rate of all-cause mortality [hazard ratio (HR) 1.62, 95% confidence interval (CI) 1.19-2.20] compared with the lowest quartile (<4.49 mg/L) (P = 0.002) In patients undergoing coronary angiography, the adjusted HRs (95% CI) for all-cause and cardiovascular mortality were 1.23 (1.0-1.51) and 1.27 (0.99-1.63) in the highest (>0.67 mg/L) compared with the lowest (<0.44 mg/L) quartile (P = 0.043 and 0.062). In both cohorts, the BTP/creatinine ratio was a stronger predictor of all-cause and cardiovascular mortality compared with BTP. BTP was associated with all-cause mortality independently of renal function in haemodialysis patients. The BTP/creatinine ratio was more predictive for all-cause and cardiovascular mortality in haemodialysis patients and individuals referred for angiography compared with BTP as single marker.
- Find related publications in this database (Keywords)
- beta-trace protein
- cardiovascular diseases
- dialysis
- kidney disease
- mortality