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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Egemnazarov, B; Crnkovic, S; Nagy, BM; Olschewski, H; Kwapiszewska, G.
Right ventricular fibrosis and dysfunction: Actual concepts and common misconceptions.
Matrix Biol. 2018; 68-69:507-521
Doi: 10.1016/j.matbio.2018.01.010
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Egemnazarov Bakytbek
- Kwapiszewska-Marsh Grazyna
- Co-authors Med Uni Graz
- Crnkovic Slaven
- Nagy Miklos Bence
- Olschewski Horst
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- Abstract:
- Fibrosis and remodeling of the right ventricle (RV) are associated with RV dysfunction and mortality of patients with pulmonary hypertension (PH) but it is unknown how much RV fibrosis contributes to RV dysfunction and mortality. RV fibrosis manifests as fibroblast accumulation and collagen deposition which may be excessive. Although extracellular matrix deposition leads to elevated ventricular stiffness, it is not known to which extent it affects RV function. Various animal models of pulmonary hypertension have been established to investigate the role of fibrosis in RV dysfunction and failure. However, they do not perfectly resemble the human disease. In the current review we describe the major characteristics of RV fibrosis, molecular mechanisms regulating the fibrotic process, and discuss how therapeutic targeting of fibrosis might affect RV function. Copyright © 2018 Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- fibrosis
- collagen
- right ventricle
- stiffness
- cardiac function