Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Brigelius-Flohé, R; Roob, JM; Tiran, B; Wuga, S; Ribalta, J; Rock, E; Winklhofer-Roob, BM.
The effect of age on vitamin E status, metabolism, and function: metabolism as assessed by labeled tocopherols.
Ann N Y Acad Sci. 2004; 1031(1):40-43
Doi: 10.1196/annals.1331.004
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Roob Johannes
- Tiran Beate
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- Abstract:
- The effects of age on vitamin E metabolism were studied in 97 healthy 20-75-year-old male nonsmoking Austrian volunteers of the VITAGE project. After a single oral intake of 30 mg d(6)-RRR-alpha- and d(2)-RRR-gamma-tocopheryl acetate, blood and 24-hour urine was collected. Deuterated tocopherols in plasma and deuterated urinary metabolites were analyzed by GC-MS. A first evaluation revealed a similar uptake of d(6)-alpha- and d(2)-gamma-tocopherol during the first 6 hours, and then d(2)-gamma-tocopherol started to decrease. Urinary d(2)-gamma- carboxyethyl hydroxychroman metabolites (CEHCs) exceeded those of d(6)-alpha-CEHCs by about 10 times. There was no effect of age. Thus, there might be no need for a higher vitamin E intake for healthy elderly nonsmoking men.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorption -
- Adult -
- Aged -
- Aging -
- Austria -
- Chromans - urine
- Deuterium - diagnostic use
- Humans - diagnostic use
- Male - diagnostic use
- Middle Aged - diagnostic use
- Nutritional Status - diagnostic use
- Propionates - urine
- Propionic Acids - urine
- Tocopherols - diagnostic use
- Vitamin E - metabolism
- alpha-Tocopherol - blood
- gamma-Tocopherol - blood
- Find related publications in this database (Keywords)
- vitamin E
- metabolism
- absorption
- alpha-tocopherol
- gamma-tocopherol
- aging
- alpha-CEHCs
- gamma-CEHCs