Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Winklhofer-Roob, BM; Meinitzer, A; Maritschnegg, M; Roob, JM; Khoschsorur, G; Ribalta, J; Sundl, I; Wuga, S; Wonisch, W; Tiran, B; Rock, E; VITAGE Study Group.
Effects of vitamin E depletion/repletion on biomarkers of oxidative stress in healthy aging.
Ann N Y Acad Sci. 2004; 1031(1):361-364
Doi: 10.1196/annals.1331.045
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Khoschsorur Gholamali
- Meinitzer Andreas
- Roob Johannes
- Tiran Beate
- Wonisch Willibald
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- Abstract:
- The effects on ex vivo LDL resistance to oxidation and biomarkers of in vivo oxidative stress in response to 3-month dietary vitamin E restriction to 25% of recommended intake and 2-month unrestricted dietary intake and supplementation with 800 IU/d were studied in 100 healthy, nonsmoking 20-75-year-old volunteers. Significant changes in vitamin E status were associated with decreases and increases, respectively, in LDL resistance to oxidation in the depletion and supplementation period and with decreases in lipid peroxidation and oxidative DNA modification in the supplementation period. Healthy aging was not associated with enhanced susceptibility to oxidation in the depletion period.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aging -
- Antioxidants - analysis
- Biological Markers - analysis
- Carotenoids - blood
- DNA - chemistry
- Erythrocytes - chemistry
- Glutathione Peroxidase - blood
- Humans -
- Lipid Peroxidation -
- Lipoproteins, LDL - blood
- Male -
- Middle Aged -
- Oxidative Stress -
- Vitamin E - administration and dosage Vitamin E - blood
- Find related publications in this database (Keywords)
- vitamin E
- dietary restriction
- supplementation
- aging
- nonsmokers
- oxidative stress
- malondialdehyde
- 8-isoprostanes
- 8-hydroxydeoxyguanosine
- peroxides
- LDL oxidation
- vitamin C
- lycopene
- beta-carotene
- glutathione peroxidase