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SHR Neuro Cancer Cardio Lipid Metab Microb

Weixler, VHM; Yates, AE; Puchinger, M; Zirngast, B; Pondorfer, P; Ratzenhofer-Komenda, B; Amegah-Sakotnik, A; Smolle-Juettner, FM; Dapunt, O.
Hyperbaric oxygen in patients with ischemic stroke following cardiac surgery: a retrospective observational trial
UNDERSEA HYPERBAR M. 2017; 44(5): 377-385.
Web of Science

Leading authors Med Uni Graz: Weixler Viktoria Heide-Marie
Co-authors Med Uni Graz: Amegah-Sakotnik Andrea; Dapunt Otto Eugen; Pondorfer-Schäfer Prisca; Puchinger Markus; Ratzenhofer-Komenda Beatrice; Smolle-Juettner Freyja-Maria; Zirngast Birgit
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Abstract:: Background: Hyperbaric oxygenation (HBO2) involves breathing 100% oxygen under elevated ambient pressure in a hyperbaric chamber, thereby dissolving oxygen in the plasma. This results in an increase of arterial partial pressure of oxygen (pO(2)). Though well established in experimental studies, HBO2 treatment for ischemic stroke is still under discussion. Methods: From 2002-2014 HBO2 (2.2 bar, 90 minutes one/day; average number per patient: 4.7) was applied in 49 consecutive patients (32 males, 17 females, mean age: 68.8 years, range 31.2 83.9) with acute neurological deficit following cardiac surgery (CABG 15; combined surgery 14; valve surgery 11;, aneurysm repair 8; malformation 1). Patients' history including TIA or stroke and carotid artery pathology were documented. Both degree and type of neurological deficit was evaluated by a scoring system (0-4) before and after HBO2 treatment. Results: Before HBO2 therapy, the average motor deficit score was 2.45 and the average speech disorder score was 0.55, as compared with an average motor deficit of 1.12 and an average speech disorder of 0.27 afterward (a=0.0001, a=0.009). The majority of patients had an overall improvement of 2 score -points after HBO2 therapy (n=23 patients). Probit analysis showed that for a 50% response/probability (LC50) of having an overall outcome of scoring points, an estimate of 4.3 111302 therapy sessions is necessary. Conclusion: 111302 therapy was associated with significant improvement in patients with acute neurological deficits due to ischemic stroke following cardiac surgery. Though this fact suggests gas embolism as the most likely cause of stroke in this collective, other underlying pathologies cannot be ruled out. Randomized studies are needed for further evaluation.
Find related publications in this database (Keywords): HBO2 therapy; cardiac surgery; neurological deficits; ischemic stroke; gas embolism