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Deinlein, T; Wolf, IH; Rainer, B; Kupsa, R; Richtig, E; Hofmann-Wellenhof, R; Zalaudek, I.
Treatment of Primary and Metastatic Multifocal Mucosal Melanoma of the Oral Cavity with Imatinib.
Case Rep Oncol. 2017; 10(2):558-563 Doi: 10.1159/000477563 [OPEN ACCESS]
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Leading authors Med Uni Graz: Kränke Teresa Maria; Zalaudek Iris
Co-authors Med Uni Graz: Hofmann-Wellenhof Rainer; Kupsa Romana; Rainer Barbara; Richtig Erika; Wolf Ingrid
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Abstract:: Mucosal melanoma of the oral cavity is a rare entity and accounts for less than 1-3% of all melanomas. Contrary to cutaneous melanoma, primary oral melanoma more commonly harbors mutations in c-KIT. A 64-year-old man presented with asymptomatic, multiple, brown-to-black macules in the oral cavity. A biopsy was taken and histopathology exhibited mucosal melanoma. In molecular analysis, a c-KIT mutation was proven and a CT scan revealed pulmonary metastases. Due to the multifocality of the lesions, the metastases, and the mutation status, a therapy with imatinib was initiated. After 1 year of therapy, progressive disease in the lung was noticed. Therefore, the therapy was switched to a PD-1 antagonist and a CTL-4 antibody. Our case suggests that imatinib may be considered as first-line treatment for both locally advanced and distant primary multifocal oral melanoma, for which surgery or radiotherapy of the primary tumor is impossible.
Find related publications in this database (Keywords): Melanoma; Mucosa; Oncology; Targeted therapy; Immuno-oncology