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SHR Neuro Cancer Cardio Lipid Metab Microb
Ozdem, S; Samanci, S; Tasatargil, A; Yildiz, A; Sadan, G; Donmez, L; Herrmann, M.
Experimental hyperhomocysteinemia disturbs bone metabolism in rats.
Scand J Clin Lab Invest. 2007; 67(7):748-756
Doi: 10.1080/00365510701342088
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- Co-authors Med Uni Graz
- Herrmann Markus
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- Abstract:
- To investigate whether experimental hyperhomocysteinemia (HHCY) can induce adverse changes in bone metabolism. Blood and urine samples were collected from rats fed with a methionine-enriched diet (HHCY, n = 18) or an isocaloric control diet (control, n = 10) for 12 weeks. Biochemical bone turnover markers (osteocalcin, hydroxyproline, N-terminal collagen I telopeptides and homocysteine (HCY), folate and vitamin B12) were measured. Whole body bone mineral density (BMD) was assessed by dual energy X-ray absorptiometry. HCY was significantly higher in HHCY than in control rats (16.2 versus 3.2 micromol/L; p = 0.0006). Bone resorption parameters hydroxyproline (1.60 +/- 0.6 versus 0.85 +/- 0.4; p<0.05) and N-terminal collagen I telopeptides (150.8 +/- 78 versus 48.1 +/- 26 nmol/L BCE; p<0.05) increased, whereas bone formation marker osteocalcin (9.01 +/- 3.8 versus 15.07 +/- 4.2 ng/mL; p<0.05) decreased in HHCY compared to control rats. The relation N-terminal collagen I telopeptides/osteocalcin significantly increased in HHCY compared to control rats (13.14 +/- 3.1 versus 4.14 +/- 1.9). BMD measurement did not reveal any differences between groups. These findings demonstrate a significant modification of bone turnover in HHCY rats. The relation between bone resorption and formation indicates a shift toward bone resorption, which might be a plausible explanation for the relation between HHCY and fracture risk.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Body Weight -
- Bone Density -
- Bone Resorption - etiology
- Bone Resorption - metabolism
- Bone and Bones - metabolism
- Collagen Type I - urine
- Creatine - urine
- Female -
- Folic Acid - blood
- Homocysteine - blood
- Hydroxyproline - urine
- Hyperhomocysteinemia - chemically induced
- Hyperhomocysteinemia - complications
- Hyperhomocysteinemia - physiopathology
- Methionine - administration & dosage
- Methionine - blood
- Osteocalcin - blood
- Osteogenesis - physiology
- Peptides - urine
- Rats -
- Rats, Wistar -
- Vitamin B 12 - blood
- Find related publications in this database (Keywords)
- biological markers
- bone
- bone density
- homocysteine
- hyperhomocysteinemia
- osteoporosis
- rats