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SHR Neuro Cancer Cardio Lipid Metab Microb
Holstein, JH; Schmalenbach, J; Herrmann, M; Ölkü, I; Garcia, P; Histing, T; Herrmann, W; Menger, MD; Pohlemann, T; Claes, L.
Excess dietary methionine does not affect fracture healing in mice.
Med Sci Monit. 2012; 18(12):BR469-BR474
Doi: 10.12659/MSM.883590
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- Co-authors Med Uni Graz
- Herrmann Markus
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- Abstract:
- An elevated serum concentration of homocysteine (hyperhomocysteinemia) has been shown to disturb fracture healing. As the essential amino acid, methionine, is a precursor of homocysteine, we aimed to investigate whether excess methionine intake affects bone repair. We analyzed bone repair in 2 groups of mice. One group was fed a methionine-rich diet (n=13), and the second group received an equicaloric control diet without methionine supplementation (n=12). Using a closed femoral fracture model, bone repair was analyzed by histomorphometry and biomechanical testing at 4 weeks after fracture. Blood was sampled to measure serum concentrations of homocysteine, the bone formation marker osteocalcin, and the bone resorption marker collagen I C-terminal crosslaps Serum concentrations of homocysteine were significantly higher in the methionine group than in the control group, while serum markers of bone turnover did not differ significantly between the 2 groups. Histomorphometry revealed no significant differences in size and tissue composition of the callus between animals fed the methionine-enriched diet and those receiving the control diet. Accordingly, animals of the 2 groups showed a comparable bending stiffness of the healing bones. We conclude that excess methionine intake causes hyperhomocysteinemia, but does not affect fracture healing in mice.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biomechanical Phenomena - drug effects
- Collagen Type I - blood
- Diet -
- Dietary Supplements -
- Femur - diagnostic imaging
- Femur - drug effects
- Femur - pathology
- Fracture Healing - drug effects
- Homocysteine - blood
- Metabolic Networks and Pathways - drug effects
- Methionine - administration & dosage
- Methionine - metabolism
- Methionine - pharmacology
- Mice -
- Osteocalcin - blood
- Peptides - blood
- Radiography -
- Find related publications in this database (Keywords)
- methionine
- homocysteine
- fracture healing
- mice