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SHR Neuro Cancer Cardio Lipid Metab Microb
Brankovič, J; Jovanovski, S; Jevnikar, P; Hofmeister, A; Reininger-Gutmann, B; Jan, J; Grošelj, M; Osredkar, J; Uršič, M; Fazarinc, G; Pogačnik, A; Vrecl, M.
Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB-155 and/or planar PCB-169.
Environ Toxicol. 2017; 32(4):1135-1146
Doi: 10.1002/tox.22309
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Hofmeister Alexander
- Reininger-Gutmann Birgit
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- Abstract:
- Exposure to widespread lipophilic and bioaccumulative polychlorinated biphenyls (PCBs) induces diverse biochemical and toxicological responses in various organs, including the bone. The aim of this study was to evaluate the changes in growth rate, geometry, serum, and bone biochemical parameters and biomechanics of juvenile rat femur induced by lactational exposure to nonplanar PCB-155 and planar PCB-169 individually and in combination. Fifteen lactating Wistar rats were divided into four groups (PCB-169, PCB-155, PCB-155+169, and control), and PCBs were administered intraperitoneally at different time points after delivery. Femurs from 22-day-old offspring were analyzed by microCT, three-point bending test and inductively coupled plasma-mass spectrometry (ICP-MS) to obtain data on bone geometry, biomechanics and mineral composition. The serum levels of calcium, phosphate and alkaline phosphatase were also determined. Lactational exposure to planar PCB-169 resulted in shorter and thinner femurs, reduced endosteal and periosteal perimeters, smaller total cross-sectional and medullary areas, and lowered serum bone marker levels and calcium levels in the bone, while femur mechanical properties were not significantly altered. The changes observed in the combination exposure (PCB-155+169) group were similar to those observed in the PCB-169 group but were less pronounced. In summary, our results demonstrate that alterations in lactationally exposed offspring were primarily induced by planar PCB-169. The milder outcome in the combined group suggested that the PCB-169-mediated toxic effects on the bone might be reduced by a nonplanar PCB-155 congener. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1135-1146, 2017. © 2016 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biomechanical Phenomena -
- Environmental Pollutants - toxicity
- Female -
- Femur - drug effects
- Femur - metabolism
- Femur - pathology
- Femur - physiopathology
- Humans -
- Lactation -
- Male -
- Polychlorinated Biphenyls - toxicity
- Rats -
- Rats, Wistar -
- Stereoisomerism -
- Find related publications in this database (Keywords)
- polychlorinated biphenyl
- femur
- growth rate
- geometry
- biomechanics