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Papousek, I; Weiss, EM; Mosbacher, JA; Reiser, EM; Schulter, G; Fink, A.
Affective processing in positive schizotypy: Loose control of social-emotional information.
Brain Cogn. 2014; 92C(50):84-91 Doi: 10.1016/j.bandc.2014.10.008
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Co-authors Med Uni Graz: Mosbacher Jochen
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Abstract:: Behavioral studies suggested heightened impact of emotionally laden perceptual input in schizophrenia spectrum disorders, in particular in patients with prominent positive symptoms. De-coupling of prefrontal and posterior cortices during stimulus processing, which is related to loosening of control of the prefrontal cortex over incoming affectively laden information, may underlie this abnormality. Pre-selected groups of individuals with low versus high positive schizotypy (lower and upper quartile of a large screening sample) were tested. During exposure to auditory displays of strong emotions (anger, sadness, cheerfulness), individuals with elevated levels of positive schizotypal symptoms showed lesser prefrontal-posterior coupling (EEG coherence) than their symptom-free counterparts (right hemisphere). This applied to negative emotions in particular and was most pronounced during confrontation with anger. The findings indicate a link between positive symptoms and a heightened impact particularly of threatening emotionally laden stimuli which might lead to exacerbation of positive symptoms and inappropriate behavior in interpersonal situations. Copyright © 2014 Elsevier Inc. All rights reserved.
Find related publications in this database (Keywords): Schizotypy; Schizotypal; Functional connectivity; EEG coherence; Top-down modulation; Social-emotional stimulation