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Wannhoff, A; Rauber, C; Friedrich, K; Rupp, C; Stremmel, W; Weiss, KH; Schemmer, P; Gotthardt, DN.
Von Willebrand factor and alkaline phosphatase predict re-transplantation-free survival after the first liver transplantation.
United European Gastroenterol J. 2017; 5(1): 86-93. Doi: 10.1177/2050640616650060 [OPEN ACCESS]
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Co-authors Med Uni Graz: Schemmer Peter
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Abstract:: After liver transplantation (LT), there are liver-related, infectious and cardiovascular complications that contribute to reduced graft survival. These conditions are associated with an increase in the Von Willebrand factor antigen (VWF-Ag), which was previously correlated with survival in cirrhotic patients. Evaluate VWF-Ag as a predictive marker of re-transplantation-free survival in patients after LT. We measured VWF-Ag in patients after first LT and then followed them prospectively with regard to the primary endpoint, namely re-transplantation-free survival. There were 6 out of 80 patients who died or received re-LT during follow-up. In these patients, the median VWF-Ag was 510.6%, which was significantly higher (p = 0.001) than in the patients who were alive at the end of follow-up (with a median VWF-Ag = 186.8%). At a cut-off of 286.8%, VWF-Ag was significantly correlated with re-transplantation-free survival (p < 0.001). VWF-Ag was independently associated with re-transplantation-free survival in a multivariate analysis; as was alkaline phosphatase (ALP), but not the model of end-stage liver disease (MELD) score, donor age, nor cold ischemia time. A score combining VWF-Ag and ALP showed an impressive capability in the receiver operating characteristic (ROC) analysis (with area under the curve (AUC) = 0.958) to distinguish between patients with regard to the primary endpoint. VWF-Ag is a non-invasive marker that can predict outcome in patients after LT. Its diagnostic performance increased when combined with ALP in a newly developed scoring system.
Find related publications in this database (Keywords): Alkaline phosphatase; diagnostic tests; liver transplantation; markers; outcome prediction; scoring system; survival; transplantation; Von Willebrand factor