Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
März, W; Kleber, ME; Scharnagl, H; Speer, T; Zewinger, S; Ritsch, A; Parhofer, KG; von Eckardstein, A; Landmesser, U; Laufs, U.
[Clinical importance of HDL cholesterol].
Herz. 2017; 42(1):58-66
Doi: 10.1007/s00059-016-4499-0
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- März Winfried
- Co-authors Med Uni Graz
- Scharnagl Hubert
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- Abstract:
- Each year 16-17 million determinations of high-density lipoprotein cholesterol (HDL-C) are conducted and interpreted in Germany. Recently acquired data have led to a fundamental reassessment of the clinical significance of HDL-C. This review article is based on a selective literature search. Low HDL‑C levels usually indicate an increased cardiovascular risk, particularly in primary prevention but the epidemiological relationship between HDL‑C and the risk is complex. The HDL plays a role in the back transport and excretion of cholesterol; however, the biological functions of HDL are dependent on the protein and lipid composition, which is not reflected by the HDL‑C concentration. If the composition of HDL is pathologically altered it can also exert negative vascular effects. Compared with low-density lipoprotein cholesterol (LDL-C), HDL‑C is of secondary importance for cardiovascular risk stratification and the calculation of the LDL-C:HDL‑C ratio is not useful for all patients. Low HDL‑C levels should prompt a search for additional metabolic and inflammatory pathologies. An increase in HDL‑C through lifestyle changes (e.g. smoking cessation and physical exercise) has positive effects and is recommended; however, HDL‑C is currently not a valid target for drug therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers - blood
- Cardiovascular Diseases - blood
- Cardiovascular Diseases - diagnosis
- Cardiovascular Diseases - mortality
- Cholesterol, HDL - blood
- Cholesterol, LDL - blood
- Evidence-Based Medicine -
- Humans -
- Prevalence -
- Reproducibility of Results -
- Risk Factors -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- High-density lipoprotein
- Low-density lipoprotein
- Cholesterol
- Cardiovascular risk
- Review