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SHR Neuro Cancer Cardio Lipid Metab Microb

Hoffmann, K; Müller-Bütow, V; Franz, C; Hinz, U; Longerich, T; Büchler, MW; Schemmer, P.
Factors predictive of survival after stapler hepatectomy of hepatocellular carcinoma: a multivariate, single-center analysis.
Anticancer Res. 2014; 34(2):767-776
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Leading authors Med Uni Graz: Schemmer Peter
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Abstract:: New technical devices for hepatic parenchymal transection have improved perioperative safety and patient survival. The aim of the present study was to determine the oncological outcome after stapler hepatectomy in patients with HCC. Data of 95 patients who underwent stapler hepatectomy for HCC between 2001 and 2011 were analyzed retrospectively regarding clinical safety of the procedure and predictive factors for survial. Thirty-nine minor (≤2 segments) and 56 major (≥3 segments) hepatic resections were performed. The median survival was 47.5 months, after 36 months follow-up. Low grading, tumors ≥5 cm, multiple nodules and liver cirrhosis were predictors of decreased overall survival using multivariate analysis with hazard ratio(HR)=2.62, 2.41, 2.05, and 1.92 respectively. An estimated intra-operative blood loss of ≥1.2l was inversely correlated to disease free survival (HR=1.96). Stapler hepatectomy is a safe procedure in patients with HCC. Substantial intraoperative blood loss and the presence of cirrhosis independently predict the overall probability of patient survival. Intraoperative blood loss directly impacts HCC recurrence.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Blood Loss, Surgical -; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Female -; Follow-Up Studies -; Hepatectomy -; Humans -; Kaplan-Meier Estimate -; Liver Neoplasms - pathology; Liver Neoplasms - surgery; Male -; Middle Aged -; Multivariate Analysis -; Neoplasm Recurrence, Local - pathology; Prognosis -; Risk Factors -; Survival Rate -; Treatment Outcome -
Find related publications in this database (Keywords): Hepatocellular carcinoma; liver resection; stapler hepatectomy; survival