Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Guan, X; Dei-Anane, G; Bruns, H; Chen, J; Nickkholgh, A; Liang, R; Gross, ML; Kern, M; Ludwig, J; Büchler, MW; Schemmer, P.
Danshen protects kidney grafts from ischemia/reperfusion injury after experimental transplantation.
Transpl Int. 2009; 22(2):232-241
Doi: 10.1111/j.1432-2277.2008.00770.x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Danshen (DS) is used for treatment of various ischemic events in the traditional Chinese medicine. Hence, this study was designed to investigate its effect on ischemia/reperfusion injury (IRI) after experimental kidney transplantation (eKTx). Nephrectomized Sprague-Dawley rats underwent eKTx. Some animals were infused with 1.5 ml DS 10 min before surgery. Kidney grafts were transplanted after cold storage for 20 h in Histidine-Tryptophane-Ketoglutarate solution. After reperfusion blood samples were collected for blood urinary nitrogen (BUN), creatinine, lactate dehydrogenase (LDH), and alanine transaminase. Further, tissue was assessed for morphologic and pathophysiologic changes. Donor preconditioning with DS (DS-d) significantly decreased BUN, creatinine, LDH, and aspartate aminotransferase to 65-97% of controls while preconditioning of the recipient (DS-r) decreased values to 58-82% (P < 0.05). Tubular damage and caspase-3 decreased significantly in both DS-d and DS-r (DS-d: 96% and 67%, DS-r: 83% and 75% of controls) while heat shock protein 72 and superoxide dismutase increased significantly (DS-d: 143% and 173%, DS-r: 166% and 194% of controls). Further, inducible nitric oxide synthase and tumor necrosis factor-alpha decreased (DS-d: 84% and 61%, DS-r: 79% and 67% of controls) after DS. Preconditioning of both donors and recipients with DS significantly reduces IRI and thus improves graft function after eKTx.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Disease Models, Animal -
- Female -
- Kidney Diseases - etiology
- Kidney Diseases - prevention & control
- Kidney Transplantation - adverse effects
- Phytotherapy -
- Plant Extracts - therapeutic use
- Plant Roots -
- Rats -
- Rats, Sprague-Dawley -
- Reperfusion Injury - etiology
- Reperfusion Injury - prevention & control
- Salvia miltiorrhiza -
- Find related publications in this database (Keywords)
- anti-oxidation
- apoptosis
- cold storage
- Danshen
- kidney transplantation
- regeneration
- reperfusion injury
- tubular damage