Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dikow, R; Degenhard, M; Kraus, T; Sauer, P; Schemmer, P; Uhl, W; Büchler, M; Zeier, M.
Blood pressure profile and treatment quality in liver allograft recipients-benefit of tacrolimus versus cyclosporine.
Transplant Proc. 2004; 36(5):1512-1515
Doi: 10.1016/j.transproceed.2004.04.096
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schemmer Peter
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- Abstract:
- Organ transplant recipients display a high cardiovascular mortality rate. The type of immunosuppression has a major impact on cardiovascular risk factors (e.g., hypertension [HTN]). We assessed 24-hour blood pressure (BP) and metabolic profiles in a cohort of 106 long-term liver allograft recipients treated with either tacrolimus (Tac) or cyclosporine (CyA). The median age of patients was 50.8 years (range, 11 to 77) and the median time of follow-up was 65.4 months (ranges 12 to 168). Immunosuppression included low-dose steroids and either Tac (n = 46) or CyA (n = 60). Twenty-four-hour BP measurements revealed a significant difference in systolic BP (127.1 mmHg [94 to 163] Tac versus 132.7 mmHg [103 to 177] CyA; P <.03), and in mean arterial and diastolic blood pressures. In addition, the relative number of normotensive patients was significantly higher among Tac-treated patients (69.6% versus 34.8%). It is of note that the true incidence of HTN was higher after the number of patients with a pathological 24-h BP measurement was added to the initial number of patients already known to have HTN. No less than 76.4% of all long-term liver transplanted patients showed HTN. The results were unrelated to cumulative steroid dosage, frequency of antirejection therapy or underlying primary liver disease. In summary, immunosuppression-induced HTN is more common in CyA-treated than Tac-based regimens. Moreover, we found a substantial lack of detection of HTN in long-term liver transplant patients who received an insufficient quality of antihypertensive treatment. These findings have implications for the early diagnosis and treatment of HTN in liver transplant recipients. Copyright 2004 Elsevier Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure - drug effects
- Blood Pressure Monitoring, Ambulatory -
- Circadian Rhythm -
- Cohort Studies -
- Cross-Sectional Studies -
- Cyclosporine - therapeutic use
- Humans -
- Immunosuppressive Agents - therapeutic use
- Liver Transplantation - immunology
- Liver Transplantation - physiology
- Survivors -
- Tacrolimus - therapeutic use