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SHR Neuro Cancer Cardio Lipid Metab Microb
Mangge, H; Zelzer, S; Prüller, F; Schnedl, WJ; Weghuber, D; Enko, D; Bergsten, P; Haybaeck, J; Meinitzer, A.
Branched-chain amino acids are associated with cardiometabolic risk profiles found already in lean, overweight and obese young.
J Nutr Biochem. 2016; 32(5):123-127
Doi: 10.1016/j.jnutbio.2016.02.007
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mangge Harald
- Co-authors Med Uni Graz
- Enko Dietmar
- Haybäck Johannes
- Meinitzer Andreas
- Prüller Florian
- Schnedl Wolfgang
- Zelzer Sieglinde
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- Abstract:
- Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juveniles (age 25.3±12.8years), classified as lean, overweight or obese. Cardiometabolic groups were defined by cutoffs of systolic blood pressure<130mmHg, diastolic blood pressure<85mmHg, glucose<125mg/dl, triglycerides<150mg/dl, HDL-cholesterol>40mg/dl (males), HDL-cholesterol>50mg/dl (females) and HOMA-IR<5. CMH had ≤1 cutoff, and cardiometabolically abnormal (CMA) had ≥2 cutoffs. Amino acids were measured by high-pressure lipid chromatography after precipitation of serum with perchloric acid and derivatization with o-phthalaldehyde. Valine correlated with 5, leucine correlated with 3 and isoleucine correlated with 5 of the cardiac risk classification factors. Valine and leucine were significantly higher in the obese (P<.001, P=.015, respectively), overweight (P<.001, P=.015, respectively) and lean (P=.024, P=.012, respectively) CMA compared to CMH subjects. Isoleucine showed except of the lean group the same results. Taken together, BCAAs, especially valine and leucine, are proposed as a cardiometabolic risk marker independent of body mass index (BMI) category. Copyright © 2016 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Amino Acids, Branched-Chain - blood
- Austria - epidemiology
- Biomarkers - blood
- Body Mass Index -
- Cardiovascular Diseases - epidemiology
- Cardiovascular Diseases - etiology
- Cross-Sectional Studies -
- Female -
- Glucose Metabolism Disorders - epidemiology
- Glucose Metabolism Disorders - etiology
- Humans -
- Incidence -
- Insulin Resistance -
- Male -
- Obesity - blood
- Obesity - metabolism
- Obesity - physiopathology
- Obesity, Metabolically Benign - blood
- Obesity, Metabolically Benign - metabolism
- Obesity, Metabolically Benign - physiopathology
- Overweight - blood
- Overweight - metabolism
- Overweight - physiopathology
- Pediatric Obesity - blood
- Pediatric Obesity - metabolism
- Pediatric Obesity - physiopathology
- Prospective Studies -
- Risk -
- Thinness - blood
- Thinness - metabolism
- Thinness - physiopathology
- Young Adult -
- Find related publications in this database (Keywords)
- Branched-chain amino acids
- Cardiometabolic risk
- Body mass index