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Selected Publication:
Häussler, S; Rohde, M; von Neuhoff, N; Nimtz, M; Steinmetz, I.
Structural and functional cellular changes induced by Burkholderia pseudomallei rhamnolipid.
Infect Immun. 2003; 71(5):2970-2975
Doi: 10.1128/IAI.71.5.2970-2975.2003
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- Steinmetz Ivo
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- Abstract:
- In this study we report that extracellular Burkholderia pseudomallei rhamnolipid induced cytopathic changes characterized by retraction, rounding up, and, finally, detachment in phagocytic and nonphagocytic cell lines. These changes were due to a progressive reorganization of the F-actin network resulting in impaired cell cycle progression and a reduced phagocytic function of macrophages.
- Find related publications in this database (using NLM MeSH Indexing)
- Actins - metabolism
- Animals -
- Burkholderia pseudomallei - pathogenicity
- Cell Cycle - drug effects
- Cell Line -
- Cytoskeleton - drug effects
- Flow Cytometry -
- GTP Phosphohydrolases - physiology
- Glycolipids - toxicity
- Mice -
- Microscopy, Fluorescence -
- Phagocytosis -