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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Gavrilov, YV; Ellison, BA; Yamamoto, M; Reddy, H; Haybaeck, J; Mignot, E; Baumann, CR; Scammell, TE; Valko, PO.
Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area.
Sleep. 2016; 39(5):1059-1062
Doi: 10.5665/sleep.5754
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- Co-authors Med Uni Graz
- Haybäck Johannes
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- Abstract:
- To examine the integrity of sleep-promoting neurons of the ventrolateral preoptic nucleus (VLPO) in postmortem brains of narcolepsy type 1 patients. Postmortem examination of five narcolepsy and eight control brains. VLPO galanin neuron count did not differ between narcolepsy patients (11,151 ± 3,656) and controls (13,526 ± 9,544). A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease. © 2016 Associated Professional Sleep Societies, LLC.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Autopsy -
- Case-Control Studies -
- Female -
- Galanin - metabolism
- Humans -
- Male -
- Narcolepsy - complications
- Narcolepsy - pathology
- Narcolepsy - physiopathology
- Neurons - metabolism
- Preoptic Area - cytology
- Preoptic Area - metabolism
- Sleep Deprivation - etiology
- Sleep Deprivation - pathology
- Sleep Deprivation - physiopathology
- Find related publications in this database (Keywords)
- galanin
- narcolepsy
- sleep fragmentation
- ventrolateral preoptic area