Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Enko, D; Kriegshäuser, G; Kimbacher, C; Stolba, R; Mangge, H; Halwachs-Baumann, G.
Carbohydrate Malabsorption and Putative Carbohydrate-Specific Small Intestinal Bacterial Overgrowth: Prevalence and Diagnostic Overlap Observed in an Austrian Outpatient Center.
Digestion. 2015; 92(1):32-38
Doi: 10.1159/000430981
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Enko Dietmar
- Co-authors Med Uni Graz
- Baumann Gabriele
- Kriegshäuser Gernot
- Mangge Harald
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- Abstract:
- While lactose malabsorption is a well-investigated condition, few epidemiologic data are available for fructose and sorbitol malabsorption. The aim of this study was to assess the prevalence rates for primary lactose malabsorption, fructose and sorbitol malabsorption, and carbohydrate-specific small intestinal bacterial overgrowth (cs-SIBO) in an Austrian outpatient center. In total, 306 adult patients, who were primarily referred with suspected carbohydrate malabsorption by general practitioners to our outpatient clinic, underwent genetic testing (C/T-13910 polymorphism) for primary lactose malabsorption, and a combined hydrogen (H2)/methane (CH4) breath test for fructose (25 g) and sorbitol (12.5 g) malabsorption. Cohen's kappa (κ) was calculated for agreement between positive breath test results and self-reported symptoms during the test. Seventy-eight (25.49%) patients were C/C-13910 homozygotes, indicating primary lactose malabsorption. Thirty-four (11.11%) and 57 (18.63%) patients were classified as fructose and sorbitol malabsorbers. Cohen's κ measuring agreements between positive fructose and sorbitol breath test results and self-reported symptoms during the test were 0.33 and 0.49, respectively. Twenty-nine (9.50%) patients with an early H2/CH4 peak (i.e. within 60 minutes after fructose and/or sorbitol ingestion) were diagnosed with cs-SIBO. In Austria, carbohydrate malabsorption is a frequent condition in patients referred by general practitioners to carbohydrate malabsorption testing. © 2015 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Ambulatory Care Facilities - statistics & numerical data
- Ambulatory Care Facilities - epidemiology
- Blind Loop Syndrome - epidemiology
- Blind Loop Syndrome - genetics
- Blind Loop Syndrome - metabolism
- Breath Tests - methods
- Female -
- Fructose - metabolism
- Fructose Intolerance - epidemiology
- Fructose Intolerance - genetics
- Homozygote -
- Humans -
- Hydrogen -
- Lactose Intolerance - epidemiology
- Lactose Intolerance - genetics
- Malabsorption Syndromes - epidemiology
- Malabsorption Syndromes - genetics
- Malabsorption Syndromes - metabolism
- Male -
- Methane -
- Middle Aged -
- Prevalence -
- Sorbitol - metabolism
- Young Adult -
- Find related publications in this database (Keywords)
- Carbohydrate malabsorption
- Small intestinal bacterial overgrowth
- Prevalence
- LCT genotyping
- Breath test