Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Matzi, V; Greilberger, JF; Lindenmann, J; Neuboeck, N; Nuhsbaumer, S; Zelzer, S; Tafeit, E; Maier, A; Smolle-Juettner, MF.
Application of Hyperbaric Oxygen Reduce Oxidative Damage of Plasmatic Carbonyl Proteins and 8-OHdG by Activating Glutathion Peroxidase.
Clin Lab. 2015; 61(5-6):587-593
Doi: 10.7754/Clin.Lab.2014.140929
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- Leading authors Med Uni Graz
- Greilberger Joachim
- Matzi Veronika
- Co-authors Med Uni Graz
- Fink-Neuböck Nicole
- Lindenmann Jörg
- Maier Alfred
- Smolle-Juettner Freyja-Maria
- Tafeit Erwin
- Zelzer Sieglinde
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- Abstract:
- It is postulated that application of hyperbaric oxygenation may induce the production of radicals after HBO. Higher oxygenation and transport of oxygen increase the mitochondrial energy turnover, whereas inner mitochondrial radical formation decreases. Several markers of oxidative stress in healthy volunteers (n = 21), including plasma carbonyl proteins (CP), malondialdehyde (MDA), oxidized LDL (oxLDL), 8-hydroxy-deoxyguanosine (8-OHdG), and erythrocyte glutathione peroxidase (GPx) activity are measured before, during, and after HBO. Median plasma concentrations of CP decreased significantly during HBO compared to CP levels before HBO (from 77.1 to 61.7 pmol/mg; p < 0.001) and increased again after HBO (to 78.1 pmol/mg; p = 0.035). 8-OHdG decreased significantly during HBO (8.1 ng/mL; p < 0.001) and remained constant after HBO (8.1 ng/mL) compared to "before HBO" (9.4 ng/mL). MDA increased significantly from 0.92 μM (before HBO) to 1.26 μM (during HBO, p < 0.01) and decreased again to 1.00 μM (after HBO, p = 0.023). Erythrocyte GPx activity also increased significantly during HBO (26.5 ± 14.7; p = 0.005), but not after HBO (25.6 ± 17.2 IU/mg). A negative correlation was observed between GPx and MDA only during HBO (r = -0.518; p = 0.016). We assume that higher oxygen consumption decreases, on the one hand, the inner mitochondrial generation of free radicals and, on the other, RONS by activation of detoxifying enzymes like GPx.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood
- Female -
- Glutathione Peroxidase - blood
- Healthy Volunteers -
- Humans -
- Hyperbaric Oxygenation -
- Lipid Peroxidation - drug effects
- Lipoproteins, LDL - blood
- Male -
- Malondialdehyde - blood
- Oxidative Stress -
- Oxygen - pharmacology Oxygen - therapeutic use
- Protein Carbonylation - drug effects
- Find related publications in this database (Keywords)
- hyperbaric oxygenation (HBO)
- carbonyl proteins (CP)
- oxidized LDL (oxLDL)
- glutathione peroxidase (GPx)
- malondialdehyde (MDA)
- 8-hydroxy-deoxyguanosine (8-OHdG)