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SHR Neuro Cancer Cardio Lipid Metab Microb
Mangge, H; Baumgartner, BG; Zelzer, S; Prüller, F; Schnedl, WJ; Reininghaus, EZ; Haybaeck, J; Lackner, C; Stauber, R; Aigner, E; Weghuber, D.
Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.
Aliment Pharmacol Ther. 2015; 42(1):99-105
Doi: 10.1111/apt.13232
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- Leading authors Med Uni Graz
- Mangge Harald
- Co-authors Med Uni Graz
- Haybäck Johannes
- Lackner Karoline
- Prüller Florian
- Reininghaus Eva
- Schnedl Wolfgang
- Stauber Rudolf
- Zelzer Sieglinde
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- Abstract:
- Obesity is associated with non-alcoholic fatty liver disease (NAFLD), and the patatin-like phospholipase 3 (PNPLA3) rs738409 (Ile148Met, C>G) gene polymorphism is one of the most important genetic determinants of NAFLD. Carriers have been reported to better respond to lifestyle modification. To investigate the effect of rs738409 on overweight/obese adolescents and adults with and without metabolic syndrome (MetS). Two hundred and eighty-eight overweight/obese and 209 normal weight participants of the STYJOBS/EDECTA cohort (NCT00482924) were analysed for PNPLA3 genotypes. Compared to overweight/obese without MetS, in overweight/obese study participants with MetS, the presence of the G allele (148Met) was significantly higher (CC: 5.0% vs. 9.2%, Spearman's correlation, 0.12; P = 0.038). Persons with CG (heterozygote for the risk allele) and with GG (homozygote for the risk allele) genotypes showed significantly higher ALT levels than those with CC genotypes. Even young individuals aged below 20 years had significantly increased ALT levels if they were homozygote with the G allele. The PNPLA3 rs738409 polymorphism is associated already in youths with increased ALT, and is more frequent in obese with MetS of all ages. Hence, overweight/obese rs738409 carriers should be identified early in life and treated with a rigorous life style intervention. © 2015 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Alleles -
- Case-Control Studies -
- Child -
- Female -
- Genotype -
- Heterozygote -
- Humans -
- Life Style -
- Lipase - genetics
- Male -
- Membrane Proteins - genetics
- Metabolic Syndrome - complications
- Metabolic Syndrome - genetics
- Middle Aged -
- Non-alcoholic Fatty Liver Disease - genetics
- Obesity - complications
- Obesity - genetics
- Polymorphism, Genetic -
- Prospective Studies -
- Young Adult -