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SHR Neuro Cancer Cardio Lipid Metab Microb
Domschke, K; Reif, A; Weber, H; Richter, J; Hohoff, C; Ohrmann, P; Pedersen, A; Bauer, J; Suslow, T; Kugel, H; Heindel, W; Baumann, C; Klauke, B; Jacob, C; Maier, W; Fritze, J; Bandelow, B; Krakowitzky, P; Rothermundt, M; Erhardt, A; Binder, EB; Holsboer, F; Gerlach, AL; Kircher, T; Lang, T; Alpers, GW; Ströhle, A; Fehm, L; Gloster, AT; Wittchen, HU; Arolt, V; Pauli, P; Hamm, A; Deckert, J.
Neuropeptide S receptor gene -- converging evidence for a role in panic disorder.
Mol Psychiatry. 2011; 16(9):938-948
Doi: 10.1038/mp.2010.81
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- Krakowitzky Petra
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- Abstract:
- Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate the role of NPS in the etiology of human anxiety. The functional NPSR A/T (Asn¹⁰⁷Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large, independent case-control studies, (2) dimensional anxiety traits, (3) autonomic arousal level during a behavioral avoidance test and (4) brain activation correlates of anxiety-related emotional processing in panic disorder. The more active NPSR rs324981 T allele was found to be associated with panic disorder in the female subgroup of patients in both samples as well as in a meta-analytic approach. The T risk allele was further related to elevated anxiety sensitivity, increased heart rate and higher symptom reports during a behavioral avoidance test as well as decreased activity in the dorsolateral prefrontal, lateral orbitofrontal and anterior cingulate cortex during processing of fearful faces in patients with panic disorder. The present results provide converging evidence for a female-dominant role of NPSR gene variation in panic disorder potentially through heightened autonomic arousal and distorted processing of anxiety-relevant emotional stimuli.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Agoraphobia - complications Agoraphobia - genetics Agoraphobia - physiopathology
- Alleles -
- Anxiety - genetics
- Anxiety Disorders - genetics
- Arousal - genetics Arousal - physiology
- Avoidance Learning - physiology
- Case-Control Studies -
- Female -
- Functional Neuroimaging - methods Functional Neuroimaging - psychology
- Genotype -
- Heart Rate - physiology
- Humans -
- Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - psychology
- Male -
- Panic Disorder - complications Panic Disorder - genetics Panic Disorder - physiopathology
- Polymorphism, Single Nucleotide - genetics
- Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - physiology
- Sex Characteristics -
- Find related publications in this database (Keywords)
- neuropeptide S
- NPS
- anxiety
- panic
- autonomic arousal
- emotional processing