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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Massone, C; Fink-Puches, R; Wolf, I; Zalaudek, I; Cerroni, L.
Atypical clinicopathologic presentation of primary cutaneous diffuse large B-cell lymphoma, leg type.
J Am Acad Dermatol. 2015; 72(6):1016-1020
Doi: 10.1016/j.jaad.2015.02.1134
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Cerroni Lorenzo
- Massone Cesare
- Co-authors Med Uni Graz
- Fink-Puches Regina
- Wolf Ingrid
- Zalaudek Iris
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- Abstract:
- Primary cutaneous diffuse large B-cell lymphoma, leg type (cDLBCL-LT) is a well-defined entity of cutaneous B-cell lymphoma affecting predominantly elderly patients, mostly women. The typical clinical presentation is characterized by solitary or multiple, rapidly growing plaques or tumors on 1 leg (rarely both legs). We sought to describe a new clinical variant of cDLBCL-LT that deviates from the conventional one. Clinical, histopathologic, phenotypical, and molecular features of 3 cases of cDLBCL-LT presenting with patches or thin plaques were reviewed (all were women, aged 60, 62, and 87 years; lesions were located on the leg in all patients). These patients presented with patches or thin plaques that represented the first manifestation of cDLBCL-LT. All 3 patients reported a history of long-standing lesions (present for 6, 9, and 18 months, respectively). Histology revealed moderately dense, perivascular infiltrates of small lymphocytes admixed with variable numbers of large cells that were CD20(+), Bcl-2(+), and MUM-1(+). There were only a small number of cases. We reported an unusual clinical presentation of cDLBCL-LT that deviates from the conventional one and that represents a formidable diagnostic challenge. Biopsy specimens of unusual patches/thin plaques or annular lesions should be obtained from the legs of adult patients if the lesions do not respond to conventional treatment. Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged, 80 and over -
- Biopsy, Needle -
- Chemoradiotherapy - methods
- Combined Modality Therapy -
- Female -
- Follow-Up Studies -
- Hematopoietic Stem Cell Transplantation - methods
- Humans -
- Immunohistochemistry -
- Leg -
- Lymphoma, Large B-Cell, Diffuse - diagnosis
- Lymphoma, Large B-Cell, Diffuse - mortality
- Lymphoma, Large B-Cell, Diffuse - pathology
- Lymphoma, Large B-Cell, Diffuse - therapy
- Lymphoma, T-Cell, Cutaneous - diagnosis
- Lymphoma, T-Cell, Cutaneous - mortality
- Lymphoma, T-Cell, Cutaneous - pathology
- Lymphoma, T-Cell, Cutaneous - therapy
- Middle Aged -
- Risk Assessment -
- Sampling Studies -
- Skin Neoplasms - mortality
- Skin Neoplasms - pathology
- Skin Neoplasms - therapy
- Survival Rate -
- Tomography, X-Ray Computed - methods
- Treatment Outcome -
- Find related publications in this database (Keywords)
- annular erythema
- clinical presentation
- cutaneous B-cell lymphoma
- primary cutaneous diffuse large B-cell lymphoma
- leg type