Medizinische Universität Graz - Research portal
Selected Publication:
Wascher, TC; Bachernegg, M; Kickenweiz, A; Stark, G; Stark, U; Toplak, H; Graier, WF.
Involvement of the L-arginine-nitric oxide pathway in hyperglycaemia-induced coronary artery dysfunction of isolated guinea pig hearts.
Eur J Clin Invest. 1996; 26(8):707-712
Doi: 10.1111/j.1365-2362.1996.tb02157.x
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Wascher Thomas
- Co-authors Med Uni Graz
- Graier Wolfgang
- Toplak Hermann
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- Abstract:
- The effects of hyperglycaemia and L-arginine on flow-induced reduction of coronary artery resistance were investigated in isolated guinea pig hearts. In the presence of indomethacin, hyperglycaemia caused an increase in flow-induced vasodilatation (P < 0.05). Hyperosmotic controls failed to mimic this effect. Addition of L-arginine strongly enhanced this effect. Addition of D-arginine failed to mimic the effects of L-arginine. The effect of L-arginine was abolished by co-administration of NG-nitro-L-arginine. In the absence of indomethacin and L-arginine, the effect of hyperglycaemia was blunted, suggesting the formation of vasoconstrictive prostanoids. Addition of L-arginine again resulted in a significant increase in flow-induced vasodilatation. In conclusion our results suggest that increased flow-induced vasodilatation under hyperglycaemic conditions depends on an adequate supply of L-arginine to maintain sufficient formation of nitric oxide.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arginine - metabolism
- Blood Circulation - drug effects
- Coronary Vessels - metabolism
- Diabetes Mellitus, Type 1 - complications
- Female - complications
- Glucose - pharmacology
- Guinea Pigs - pharmacology
- Heart Rate - drug effects
- Hyperglycemia - metabolism
- Indomethacin - pharmacology
- Male - pharmacology
- NG-Nitroarginine Methyl Ester - pharmacology
- Nitric Oxide - metabolism
- Perfusion - metabolism
- Vascular Resistance - drug effects
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Coronary Arteries
- Diabetes
- Hyperglycemia
- L-Arginine
- Nitric Oxide