Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mueller, AA; Sader, R; Honigmann, K; Zeilhofer, HF; Schwenzer-Zimmerer, K.
Central nervous malformations in presence of clefts reflect developmental interplay.
Int J Oral Maxillofac Surg. 2007; 36(4): 289-295.
Doi: 10.1016/j.ijom.2006.10.018
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Schwenzer-Zimmerer Katja Christine
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- Abstract:
- Children with cleft lip and/or cleft palate (CLP) often have additional congenital malformations. The reported incidences are variable and presumed underlying mechanisms are rarely discussed. In this study, 245 CLP patients of a geographically defined population were retrospectively reviewed for additional major malformations and minor anomalies. Malformation incidences in the CLP population were compared to those in a literature-based cohort from the general population. Of the CLP patients, 21% showed either major malformations or minor anomalies. In one-fifth of them a recognized syndrome was identified. Two thirds of the CLP patients with minor anomalies also had major malformations. Major malformations in non-syndromic CLP patients were found with decreasing frequency in the musculoskeletal (5.1%), central nervous (4.2%), urogenital (3.8%) and cardiovascular (3.4%) systems. Malformations in these organ systems and minor anomalies should be ruled out by a specialist. The rise in malformation incidence, when compared to the general population, was highest for organs of ectodermal and ecto-mesodermal origin: central nervous system (13 times), ocular (7 times) and craniofacial system (7 times). The result reflects the close interplay of craniofacial and brain development.
- Find related publications in this database (using NLM MeSH Indexing)
- Abnormalities, Multiple - epidemiology
- Cardiovascular Abnormalities - epidemiology
- Child, Preschool -
- Cleft Lip - epidemiology
- Cleft Palate - epidemiology
- Cohort Studies -
- Craniofacial Abnormalities - epidemiology
- Cross-Sectional Studies -
- Cross-Sectional Studies - epidemiology
- Eye Abnormalities - epidemiology
- Humans -
- Incidence -
- Infant -
- Infant, Newborn -
- Musculoskeletal Abnormalities - epidemiology
- Nervous System Malformations - epidemiology
- Retrospective Studies -
- Syndrome -
- Urogenital Abnormalities - epidemiology
- Find related publications in this database (Keywords)
- cleft lip
- cleft palate
- multiple abnormalities
- associations
- malformations
- congenital