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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kröpfl, JM; Stelzer, I; Mangge, H; Pekovits, K; Fuchs, R; Allard, N; Schinagl, L; Hofmann, P; Dohr, G; Wallner-Liebmann, S; Domej, W; Müller, W.
Exercise-induced norepinephrine decreases circulating hematopoietic stem and progenitor cell colony-forming capacity.
PLoS One. 2014; 9(9):e106120
Doi: 10.1371/journal.pone.0106120
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- Leading authors Med Uni Graz
- Kröpfl Julia
- Stelzer Ingeborg
- Co-authors Med Uni Graz
- Dohr Gottfried
- Domej Wolfgang
- Fuchs Robert
- Holasek Sandra Johanna
- Mangge Harald
- Meier-Allard Nathalie
- Müller Wolfram
- Pekovits Karin
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- Abstract:
- A recent study showed that ergometry increased circulating hematopoietic stem and progenitor cell (CPC) numbers, but reduced hematopoietic colony forming capacity/functionality under normoxia and normobaric hypoxia. Herein we investigated whether an exercise-induced elevated plasma free/bound norepinephrine (NE) concentration could be responsible for directly influencing CPC functionality. Venous blood was taken from ten healthy male subjects (25.3+/-4.4 yrs) before and 4 times after ergometry under normoxia and normobaric hypoxia (FiO2<0.15). The circulating hematopoietic stem and progenitor cell numbers were correlated with free/bound NE, free/bound epinephrine (EPI), cortisol (Co) and interleukin-6 (IL-6). Additionally, the influence of exercise-induced NE and blood lactate (La) on CPC functionality was analyzed in a randomly selected group of subjects (n = 6) in vitro under normoxia by secondary colony-forming unit granulocyte macrophage assays. Concentrations of free NE, EPI, Co and IL-6 were significantly increased post-exercise under normoxia/hypoxia. Ergometry-induced free NE concentrations found in vivo showed a significant impairment of CPC functionality in vitro under normoxia. Thus, ergometry-induced free NE was thought to trigger CPC mobilization 10 minutes post-exercise, but as previously shown impairs CPC proliferative capacity/functionality at the same time. The obtained results suggest that an ergometry-induced free NE concentration has a direct negative effect on CPC functionality. Cortisol may further influence CPC dynamics and functionality.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Antigens, CD34 - metabolism
- Blood Cell Count - administration & dosage
- Cell Hypoxia - administration & dosage
- Cell Proliferation - administration & dosage
- Colony-Forming Units Assay - administration & dosage
- Epinephrine - blood
- Ergometry - administration & dosage
- Exercise - administration & dosage
- Hematopoietic Stem Cells - cytology
- Humans - administration & dosage
- Hydrocortisone - blood
- Interleukin-6 - blood
- Lactates - blood
- Leukocyte Common Antigens - metabolism
- Male - administration & dosage
- Norepinephrine - blood