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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mäkelä, KM; Traylor, M; Oksala, N; Kleber, ME; Seppälä, I; Lyytikäinen, LP; Hernesniemi, JA; Kähönen, M; Bevan, S; Rothwell, PM; Sudlow, C; Dichgans, M; Wellcome Trust Case Control Consortium 2 (WTCCC2); Delgado, G; Grammer, TB; Scharnagl, H; Markus, HS; März, W; Lehtimäki, T.
Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events.
Atherosclerosis. 2014; 234(1):214-217
Doi: 10.1016/j.atherosclerosis.2014.03.002
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- Co-authors Med Uni Graz
- März Winfried
- Scharnagl Hubert
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- Abstract:
- Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD). The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls). In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke. The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain Ischemia - blood
- Brain Ischemia - complications
- Brain Ischemia - genetics
- Cerebrovascular Disorders - blood
- Cerebrovascular Disorders - genetics
- Female -
- Humans -
- Lipoproteins, LDL - blood
- Lipoproteins, LDL - genetics
- Male -
- Polymorphism, Single Nucleotide -
- Stroke - blood
- Stroke - etiology
- Stroke - genetics
- Find related publications in this database (Keywords)
- Oxidized low-density lipoprotein
- Stroke
- Transient ischaemic attack
- Genetics
- Single nucleotide polymorphism