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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Birkl, C; Langkammer, C; Haybaeck, J; Ernst, C; Stollberger, R; Fazekas, F; Ropele, S.
Temperature Dependency of T1 Relaxation Time in Unfixed and Fixed Human Brain Tissue.
Biomed Tech (Berl). 2013; 58 Suppl 1(1):
Doi: 10.1515/bmt-2013-4290
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Birkl Christoph
- Co-authors Med Uni Graz
- Ernst Christina
- Fazekas Franz
- Haybäck Johannes
- Langkammer Christian
- Ropele Stefan
- Stollberger Rudolf
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- Abstract:
- MR relaxation times of most tissues are expected to depend on temperature which can impact findings in post mortem MRI or MRI based thermometry. The purpose of this study was to investigate the exact temperature dependency of the T-1 relaxation in different structures in unfixed and fixed human brain samples. Following autopsy, coronal brain slices from five deceased subjects underwent MRI at 3T in a temperature range between 4 degrees C and 37 degrees C. T1 showed a linear dependency on temperature with the highest temperature coefficient in the cortex (17 ms/degrees C) and the lowest in the white matter (3ms/degrees C). The fixation of the tissue lowered T1 and additionally the temperature coefficient in all regions investigated. The temperature coefficients obtained in this study serve as reference for thermometry and for correcting quantitative post mortem MRI.
- Find related publications in this database (Keywords)
- magnetic resonance imaging
- temperature
- T-1 relaxation time
- human brain tissue
- fixation