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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Stefulj, J; Panzenboeck, U; Hof, PR; Simic, G; .
Pathogenesis, modulation, and therapy of Alzheimer's disease: A perspective on roles of liver-X receptors.
TRANSL NEUROSCI. 2013; 4(3): 349-356.
Doi: 10.2478/s13380-013-0136-z
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- Leading authors Med Uni Graz
- Stefulj Jasminka
- Co-authors Med Uni Graz
- Panzenboeck Ute
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- Abstract:
- The pathogenesis of Alzheimer's disease (AD) has been mostly linked to aberrant amyloid beta (A beta) and tau proteins metabolism, disturbed lipid/cholesterol homeostasis, and progressive neuroinflammation. Liver X receptors (LXR) are ligand-activated transcription factors, best known as the key regulators of cholesterol metabolism and transport. In addition, LXR signaling has been shown to have significant anti-inflammatory properties. In this brief review, we focus on the outcome of studies implicating LXR in the pathogenesis, modulation, and therapy of AD.
- Find related publications in this database (Keywords)
- Alzheimer's disease
- Neurodegeneration
- Amyloid-beta
- Cholesterol
- Liver-X receptors
- LXR agonists
- Neuroinflammation
- Transgenic mouse models