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SHR Neuro Cancer Cardio Lipid Metab Microb

Manzini, G; Kremer, M; Houben, P; Gondan, M; Bechstein, WO; Becker, T; Berlakovich, GA; Friess, H; Guba, M; Hohenberger, W; Ijzermans, JN; Jonas, S; Kalff, JC; Klar, E; Klempnauer, J; Lerut, J; Lippert, H; Lorf, T; Nadalin, S; Nashan, B; Otto, G; Paul, A; Pirenne, J; Pratschke, J; Ringers, J; Rogiers, X; Schilling, MK; Seehofer, D; Senninger, N; Settmacher, U; Stippel, DL; Tscheliessnigg, K; Ysebaert, D; Binder, H; Schemmer, P.
Reperfusion of liver graft during transplantation: techniques used in transplant centres within Eurotransplant and meta-analysis of the literature.
Transpl Int. 2013; 26(5):508-516 Doi: 10.1111/tri.12083 [OPEN ACCESS]
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Leading authors Med Uni Graz: Schemmer Peter
Co-authors Med Uni Graz: Tscheliessnigg Karlheinz
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Abstract:: It remains unclear which liver graft reperfusion technique leads to the best outcome following transplantation. An online survey was sent to all transplant centres (n = 37) within Eurotransplant (ET) to collect information on their technique used for reperfusion of liver grafts. Furthermore, a systematic review of all literature was performed and a meta-analysis was conducted based on patients' mortality, number of retransplantations and incidence of biliary complications, depending on the technique used. Of the 28 evaluated centres, 11 (39%) reported performing simultaneous reperfusion (SIMR), 13 (46%) perform initial portal vein reperfusion (IPR), 1 (4%) performs an initial hepatic artery reperfusion (IAR) and 3 (11%) perform retrograde reperfusion (RETR). In 21 centres (75%), one reperfusion technique is used as a standard, but in only one centre is this decision based on available literature. Twenty centres (71%) said they would agree to participate in randomized controlled trials (RCT) if required. For meta-analysis, IAR vs. IPR, SIMR vs. IPR and RETR vs. IPR were compared. There was no difference between any of the techniques compared. There is no consensus on a preferable reperfusion technique. Available evidence does not help in the decision-making process. There is thus an urgent need for multicentric RCTs. © 2013 The Authors Transplant International © 2013 European Society for Organ Transplantation. Published by Blackwell Publishing Ltd.
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Find related publications in this database (Keywords): liver reperfusion; retrograde reperfusion; sequential reperfusion; simultaneous reperfusion