Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Urlesberger, B; Zobel, G; Rödl, S; Dacar, D; Friehs, I; Leschnik, B; Muntean, W.
Activation of the clotting system: heparin-coated versus non coated systems for extracorporeal circulation.
INT J ARTIF ORGANS 1997 20: 708-712.
Doi: 10.1177/039139889702001211
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- Führende Autor*innen der Med Uni Graz
- Urlesberger Berndt
- Co-Autor*innen der Med Uni Graz
- Dacar Drago
- Leschnik Bettina
- Muntean Eugen
- Roedl Siegfried
- Zobel Gerfried
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- Abstract:
- The purpose of this experimental study was to compare heparin-coated versus non-coated systems for extracorporeal membrane oxygenation (ECMO), to investigate the dynamic course of clotting activation in both groups. METHODS: Eight pigs weighing 19.7 (+/- 1.3) kg, each underwent ECMO for 24 hours. Two groups were formed: in group 1, heparin-coated circuits were used with low dose heparinization (10 IU/kg/hr), whereas in group 2 non-coated circuits with high dose heparinization (60 IU/kg/hr) were used. Coagulation was monitored by measuring prothrombin time, partial thromboplastin time, fibrinogen, antithrombin III (AT III) and specific markers of clotting activation (thrombin-antithrombin III complexes (TAT) and D-dimer). Furthermore, platelet count, hematocrit, activated clotting time (ACT), and plasma heparin concentration were determined regularly RESULTS: The dynamic course of the specific coagulation activation markers showed some differences: whereas TAT and D-dimer increased quickly in group 2, the increase in group 1 was delayed. Activation marker values tended to be lower in group 1 during the first six hours, after which no more differences between the groups were seen. After 24 hours of ECMO, TAT and D-dimer had nearly returned to baseline values. Platelets showed a continuous decrease throughout the experiment, which was very similar in both groups. CONCLUSIONS: The heparin coated system showed a distinct delay in clotting activation during the first six hours of ECMO. After six hours there were no more differences between the groups.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anticoagulants - pharmacology
- Antithrombin III - analysis
- Biocompatible Materials - analysis
- Blood Coagulation - drug effects
- Comparative Study - drug effects
- Extracorporeal Membrane Oxygenation - drug effects
- Female - drug effects
- Fibrinogen - analysis
- Hematocrit - analysis
- Heparin - blood
- Male - blood
- Membranes, Artificial - blood
- Partial Thromboplastin Time - blood
- Peptide Hydrolases - analysis
- Platelet Count - analysis
- Prothrombin Time - analysis
- Swine - analysis
- Find related publications in this database (Keywords)
- Extracorporeal Membrane Oxygenation
- Animal Experiment
- Heparin-Coated Circuit
- Clotting Activation