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Tiran, A; Tio, RA; Oostenveld, E; Harmsen, MC; Tiran, B; Den Heijer, P; Monnink, SH; Wilders-Truschnig, MM; The, TH.
Humoral immune response to human cytomegalovirus in patients undergoing percutaneous transluminal coronary angioplasty.
Clin Diagn Lab Immunol. 1999; 6(1):45-49 Doi: 10.1128/CDLI.6.1.45-49.1999 [OPEN ACCESS]
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Leading authors Med Uni Graz
Tiran Andreas
Co-authors Med Uni Graz
Tiran Beate
Truschnig-Wilders Martini
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Abstract:
Possible causal relations between prior human cytomegalovirus (HCMV) infection and atherosclerosis and between HCMV reactivation and restenosis after coronary angioplasty have been suggested. We investigated patterns of antibodies directed to HCMV in 112 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) and in a group of sex- and age-matched controls (blood donors without evidence of atherosclerosis). Levels of antibodies to HCMV were measured by enzyme-linked immunosorbent assay (ELISA) of serum samples drawn before and 5 weeks after PTCA. To further differentiate the humoral immune response, we specifically tested antibody reactivity towards four single HCMV proteins (IE2, p52, pp150, and pp65) by recombinant ELISAs. We found that 73% of PTCA patients and 69% of sex- and age-matched controls were seropositive for HCMV (odds ratio, 1.2 [not significant]). The corresponding odds ratios for matched pairs ranged in the recombinant ELISAs from 1.2 to 1.4. Patients had more often high titers of anti-HCMV antibodies (11 versus 4%; odds ratio = 3.3 [0.9 to 15.2]; P = 0.052) and high titers of anti-pp150 antibodies (13 versus 4%; odds ratio = 6.0 [1.3 to 38.8]; P = 0.008). Anti-HCMV immunoglobulin M antibodies were not detected in any patient. There was no evidence of acute HCMV reactivation after PTCA, since the titers of antibodies to the investigated recombinant proteins did not increase at 5 weeks after PTCA. Our results show a limited association between prior HCMV infection and coronary artery disease. We infer that positive anti-HCMV titers are not a major risk factor at the time of disease manifestation. However, this study cannot rule out a possible role of HCMV at earlier stages of the atherosclerotic process. Recombinant ELISAs provide a valuable tool for investigating the antiviral immune response.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Angioplasty, Transluminal, Percutaneous Coronary - adverse effects
Antibodies, Viral - blood
Antigens, Viral - genetics
Arteriosclerosis - etiology
Case-Control Studies - etiology
Cytomegalovirus - genetics
Cytomegalovirus Infections - complications
Enzyme-Linked Immunosorbent Assay - methods
Female - methods
Humans - methods
Male - methods
Middle Aged - methods
Prospective Studies - methods
Recombinant Proteins - genetics
Recurrence - genetics
Risk Factors - genetics
Time Factors - genetics

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