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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofer, N; Zacharias, E; Muller, W; Resch, B; .
Performance of the definitions of the systemic inflammatory response syndrome and sepsis in neonates.
J Perinat Med. 2012; 40(5):587-590
Doi: 10.1515/jpm-2011-0308
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Hofer Nora
- Co-authors Med Uni Graz
- Müller Wilhelm
- Resch Bernhard
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- Abstract:
- Aims: The aim of this study was to examine the applicability of the definitions of the systemic inflammatory response syndrome (SIRS) and sepsis to neonates during the first 3 days of life. Methods: This is a retrospective study of all term neonates hospitalized within the first 24 h of life from 2004 to 2010 at our neonatal intensive care unit. Results: Of 476 neonates, 30 (6%) had a diagnosis of culture-proven early-onset sepsis (EOS) and 81 (17%) had culture-negative clinical EOS or suspected EOS. SIRS and sepsis criteria were applied to 116 (24%) and 61 (13%) neonates, respectively. Of 30 neonates with culture proven, EOS 14 (53%) fulfilled SIRS and sepsis criteria. The single diagnostic criterion of SIRS applied to 20% (hypothermia or fever), 43% (white blood cell count/immature-to-total neutrophil ratio), 87% (respiratory symptoms), and 33% (cardiocirculatory symptoms) of all neonates with culture-proven EOS. Conclusions: The definitions of SIRS and sepsis did not apply to about half of all cases of culture-proven EOS. An evidence-based approach to find the appropriate criteria for defining EOS in the neonate is needed.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Humans -
- Infant, Newborn -
- Infant, Newborn, Diseases - diagnosis
- Male -
- Retrospective Studies -
- Sepsis - diagnosis
- Terminology as Topic -
- Find related publications in this database (Keywords)
- Bacterial infection
- early-onset sepsis
- neonatal sepsis
- newborn infant
- systemic inflammatory response syndrome