Medizinische Universität Graz - Research portal
Selected Publication:
Hutter, H; Dohr, G.
HLA expression on immature and mature human germ cells.
J Reprod Immunol. 1998; 38(2):101-122
Doi: 10.1016%2FS0165-0378%2898%2900032-1
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- Leading authors Med Uni Graz
- Hutter Heinz
- Co-authors Med Uni Graz
- Dohr Gottfried
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- Abstract:
- Human leukocyte antigens (HLA) are membrane-bound glycoproteins encoded by the human major histocompatibility complex located on chromosome 6. They are known to function in immnunologic recognition and, with regard to reproduction, a number of non-immune functions have been proposed. Although the expression patterns of the major histocompatibility antigens have been extensively studied at the maternal fetal interface, there are still controversial reports on the expression of these molecules by human gametes and preimplantation stages. This brief review focuses on recent studies where the expression and distribution of HLA on human spermatogenic cells (spermatogonia, primary and secondary spermatocytes, spermatids, spermatozoa), primary and secondary oocytes, and preimplantation embryos have been investigated. These results, and their possible implications for the fertilization process and further embryonic development, will be presented.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Embryonic Development -
- Female -
- Gene Expression -
- HLA Antigens - biosynthesis
- Humans - biosynthesis
- Major Histocompatibility Complex - biosynthesis
- Male - biosynthesis
- Ovum - immunology
- Pregnancy - immunology
- Spermatozoa - immunology
- Find related publications in this database (Keywords)
- Spermatogenic Cells
- Oocytes
- Major Histocompatibility Complex (MHC)
- Human Leukocyte Antigens (HLA)