Medizinische Universität Graz - Research portal
Selected Publication:
Hammer, A; Hutter, H; Dohr, G.
HLA class I expression on the materno-fetal interface.
Am J Reprod Immunol. 1997; 38(3):150-157
Doi: 10.1111/j.1600-0897.1997.tb00291.x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hammer Astrid
- Co-authors Med Uni Graz
- Dohr Gottfried
- Hutter Heinz
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- PROBLEM: The conditions that permit the genetically dissimilar (haplo-non-identical) human fetus to evade rejection by its mothers immune system have been the subject of intense interest for several years. As the placental cells, which are in contact with maternal blood or tissue, are devoid of HLA class II antigens, the interest has focused on the expression of HLA class I molecules. METHOD OF STUDY: Recent findings on the constitutive, transcriptional, and translational expression of HLA class I molecules on anatomically and morphologically different subpopulations of trophoblast cells will form the basis of this article. RESULTS: The expression of HLA class I molecules in the trophoblast cells, forming the materno-fetal junctional zone is inhomogeneous. It differs depending on the differentiation and location of trophoblast cells within the placenta and furthermore on the stage of gestation. On the transcriptional level HLA-A, -B, -C, -E, and -G could be detected on individual trophoblast populations, whereas only HLA-C and HLA-G seem to be translated to protein. CONCLUSIONS: The expression of HLA class I antigens by trophoblast cells is not simply suppressed. Instead, less polymorphic HLA-G and HLA-C antigens are carefully selected from the class I multigene family. This gives rise to the assumption that these two HLA class I molecules play an important role in the maintenance of pregnancy.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Gene Expression -
- Genes, MHC Class I -
- HLA Antigens - genetics
- Histocompatibility Antigens Class I - genetics
- Humans - genetics
- Maternal-Fetal Exchange - immunology
- Placenta - anatomy and histology
- Pregnancy - anatomy and histology
- RNA, Messenger - genetics
- Find related publications in this database (Keywords)
- HLA Class I Molecules
- Human Placenta
- Immunology
- Trophoblast Cells