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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bornemann-Cimenti, H; Lederer, AJ; Wejbora, M; Michaeli, K; Kern-Pirsch, C; Archan, S; Rumpold-Seitlinger, G; Zigeuner, R; Sandner-Kiesling, A.
Preoperative pregabalin administration significantly reduces postoperative opioid consumption and mechanical hyperalgesia after transperitoneal nephrectomy.
Br J Anaesth. 2012; 108(5): 845-849.
Doi: 10.1093/bja/aes004
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- Leading authors Med Uni Graz
- Bornemann-Cimenti Helmar
- Sandner-Kiesling Andreas
- Co-authors Med Uni Graz
- Farzi Sylvia Ingrid
- Kern-Pirsch Claudia
- Michaeli Kristina Daniela
- Rumpold-Seitlinger Gudrun
- Wejbora Mischa
- Zigeuner Richard
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- Abstract:
- BACKGROUND: Preoperative administration of pregabalin is proposed as a promising way of enhancing postoperative pain control. Whereas a few studies have investigated the effect of pregabalin on postoperative opioid consumption, no study has focused on the influence on postoperative hyperalgesia. In this randomized, triple-blinded, placebo-controlled study, we aimed to demonstrate that a single, preoperative dose of pregabalin reduces postoperative opioid consumption, mechanical hyperalgesia, and pain sensitivity. METHODS: Patients undergoing elective transperitoneal nephrectomy received 300 mg pregabalin or placebo 1 h before anaesthesia. After operation, patients received piritramide via a patient-controlled analgesia device. Pain levels and side-effects were documented. The area of hyperalgesia for punctuate mechanical stimuli around the incision was measured 48 h after the operation with a hand-held von Frey filament. Mechanical pain threshold was tested before and 48 h after surgery with von Frey filaments with increasing diameters. RESULTS: In each group, 13 patients were recruited. Total piritramide consumption [77 (16) vs 52 (16) mg, P=0.0004] and the normalized area of hyperalgesia [143 (87) vs 84 (54) cm(2), P=0.0497] were significantly decreased in the pregabalin group. There were no significant differences in mechanical pain threshold levels [1.20 (0.56) log(g) vs 1.05 (0.58) log(g), P=0.6738]. No case of severe sedation was reported in both groups. No other side-effects were observed. CONCLUSIONS: Our study has shown that preoperative administration of 300 mg pregabalin in patients undergoing transperitoneal nephrectomy reduces postoperative opioid consumption and decreases the area of mechanical hyperalgesia.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Analgesics, Non-Narcotic - administration and dosage
- Analgesics, Opioid - administration and dosage
- Double-Blind Method -
- Drug Administration Schedule -
- Drug Therapy, Combination -
- Female -
- Humans -
- Hyperalgesia - etiology
- Male -
- Middle Aged -
- Nephrectomy - adverse effects
- Pain Measurement - methods
- Pain Threshold - drug effects
- Pain, Postoperative - prevention and control
- Preanesthetic Medication - methods
- gamma-Aminobutyric Acid - administration and dosage
- Find related publications in this database (Keywords)
- analgesics
- opioids
- hyperalgesia
- nephrectomy
- pain
- postoperative
- pain threshold
- preanaesthetic medication
- pregabalin