Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lembeck, F; Griesbacher, T.
Functional analysis of kinin antagonists.
J Cardiovasc Pharmacol. 1990; 15 Suppl 6(3):S75-S77
Doi: 10.1097/00005344-199000156-00014
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Lembeck Fred
- Co-Autor*innen der Med Uni Graz
- Griesbacher Thomas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Peptide analogs of bradykinin (BK) containing unusual amino acids are potent antagonists of the actions of BK in various smooth muscle preparations. Apparent pA2 values above 7.0 could be demonstrated for Lys-Lys-[Hyp3, Thi5.8, D-Phe7]-BK (B4310) in the rat uterus and the rat duodenum. Actions of BK that are related to its possible role in inflammation could be antagonized in a specific and dose-dependent manner by B4310. Stimulation by BK of C fiber afferent neurons was investigated in the rabbit ear reflex preparation and in the isolated rabbit iris sphincter muscle. In both preparations, B4310 caused a parallel shift of the dose-response curves to BK. In the latter case, a pA2 value was established that agrees well with the values found on smooth muscles. However, the short duration of action of the antagonists suggested a rapid inactivation by peptidases.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Bradykinin - analogs and derivatives
- Female - analogs and derivatives
- Inflammation - physiopathology
- Kallidin - analogs and derivatives
- Kinins - antagonists and inhibitors
- Lung - drug effects
- Mice - drug effects
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Neurons, Afferent - drug effects
- Rats - drug effects
- Rats, Inbred Strains - drug effects
- Regional Blood Flow - drug effects
- Skin - drug effects