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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pilz, S; Dobnig, H; Tomaschitz, A; Kienreich, K; Meinitzer, A; Friedl, C; Wagner, D; Piswanger-Sölkner, C; März, W; Fahrleitner-Pammer, A.
Low 25-hydroxyvitamin D is associated with increased mortality in female nursing home residents.
J Clin Endocrinol Metab. 2012; 97(4): E653-E657.
Doi: 10.1210/jc.2011-3043
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- Leading authors Med Uni Graz
- Pilz Stefan
- Co-authors Med Uni Graz
- Dobnig Harald
- Fahrleitner-Pammer Astrid
- Kienreich Katharina
- Lackner Claudia
- Lipp-Solkner Claudia
- März Winfried
- Meinitzer Andreas
- Tomaschitz Andreas
- Wagner Doris
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- Abstract:
- CONTEXT: Vitamin D deficiency contributes to skeletal diseases and is highly prevalent among institutionalized elderly patients. Whether low 25-hydroxyvitamin D (25[OH]D) concentrations are an independent risk factor for mortality in these patients is, however, unclear. OBJECTIVE: We aimed to evaluate whether 25(OH)D concentrations are associated with mortality. DESIGN, SETTING, AND PARTICIPANTS: This is a prospective cohort study among elderly female patients (age >70 yr) recruited from 95 nursing homes in Austria. MAIN OUTCOME MEASURES: We calculated Cox proportional hazard ratios (HR) for all-cause mortality according to 25(OH)D quartiles. RESULTS: We examined 961 study participants (age 83.7 ± 6.1 yr). Median 25(OH)D concentration was 17.5 (interquartile range 13.7-25.5) nmol/liter, and 93% of our cohort had 25(OH)D levels below 50 nmol/liter. During a mean follow-up time of 27 ± 8 months, 284 patients died. Compared with the fourth quartile (25[OH]D >25.5 nmol/liter), the age-adjusted HR (with 95% confidence interval) was 1.49 (1.07-2.10) in the first 25(OH)D quartile (25[OH]D <14.0 nmol/liter), and this association remained significant after multivariate adjustments (HR = 1.56; 95% confidence interval = 1.01-2.40). CONCLUSIONS: This Austrian study suggests that the majority of institutionalized female patients are vitamin D deficient during winter and that there was an inverse association of 25(OH)D and mortality. These data underscore the urgent need for effective strategies for the prevention and treatment of vitamin D deficiency, in particular in the setting of nursing homes.
- Find related publications in this database (using NLM MeSH Indexing)
- 25-Hydroxyvitamin D 2 - blood
- Aged -
- Aged, 80 and over -
- Aging -
- Aging - epidemiology
- Calcifediol - blood
- Cohort Studies -
- Female -
- Follow-Up Studies -
- Frail Elderly -
- Homes for the Aged -
- Humans -
- Mortality -
- Multivariate Analysis -
- Nursing Homes -
- Prevalence -
- Proportional Hazards Models -
- Prospective Studies -
- Seasons -
- Vitamin D Deficiency - blood