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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hofer, N; Müller, W; Resch, B.
Neonates presenting with temperature symptoms: Role in the diagnosis of early onset sepsis.
Pediatr Int. 2012; 54(4):486-490
Doi: 10.1111/j.1442-200X.2012.03570.x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Hofer Nora
- Co-authors Med Uni Graz
- Müller Wilhelm
- Resch Bernhard
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- Abstract:
- Background: In this study, we aimed to evaluate the role of fever, hypothermia, and temperature instability in term and preterm newborns during the first 3 days of life and to identify risk factors for early onset sepsis (EOS) among newborns presenting with these temperature symptoms. Methods: In this retrospective cohort study set in our level III neonatal intensive care unit, we included all newborns hospitalized within the first 24 h of life from 2004 to 2007. Results: Of 851 newborns, 127 presented with temperature symptoms during the first 3 days of life (15%): 69 had fever, 69 had hypothermia, and 55 had temperature instability (8%, 8%, and 6%, respectively). Of 127 newborns presenting with temperature symptoms, 14 had culture-proven EOS/pneumonia (33% of all 42 newborns with culture-proven EOS/pneumonia), 67 had clinical EOS (30% of all 209 newborns with clinical EOS) and 46 were EOS-negative (8% of all 600 EOS-negatives). Factors associated with culture-proven EOS/pneumonia in newborns presenting with temperature symptoms were maternal fever (P= 0.009), chorioamnionitis (P < 0.001), antibiotic therapy of the mother (P= 0.04), poor skin color (P= 0.001) and syndrome of persistent fetal circulation (P= 0.01). Conclusions: Every seventh newborn hospitalized at our neonatal intensive care unit developed fever, hypothermia and/or temperature instability during the first 3 days of life. Two-thirds of them had culture-proven or clinical sepsis. Temperature symptoms were rarely observed in EOS-negative newborns (8%) but despite low sensitivity, were highly specific for bacterial infection in preterm and term newborns.
- Find related publications in this database (using NLM MeSH Indexing)
- Cohort Studies -
- Early Diagnosis -
- Female -
- Fever - epidemiology
- Hospitalization -
- Humans -
- Hypothermia - epidemiology
- Infant, Newborn -
- Male -
- Prevalence -
- Retrospective Studies -
- Risk Factors -
- Sepsis - complications
- Find related publications in this database (Keywords)
- bacterial infection
- fever
- hypothermia
- neonatal sepsis
- newborn infant